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Article
Semi-synthesis and in vitro anti-cancer effects evaluation of novel xanthohumol derivatives
Xanthohumol (Xn) is a chalcone compound isolated from Humulus lupulus Linn., that has various biological activities. In this study, eight Xn derivatives were synthesized by Williamson, Mannich, Reimer-Tiemann, an...
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Article
Anti-cancer effects of methanol-ethyl acetate partitioned fraction from Magnolia grandiflora in human non-small cell lung cancer H1975 cells
Non-small cell lung cancer (NSCLC) constitutes nearly 85% of all cases of lung cancer. Drug resistance, dose-limiting toxicity, and metastasis in NSCLC eventually reduce the efficacy of chemotherapeutics. In t...
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Article
Bishonokiol A inhibits breast cancer cell invasion and migration by suppressing hypoxia inducible factor-1α
Hypoxia inducible factor-1α (HIF-1α) plays a central role in cell survival, invasion, metastasis and angiogenesis, and also is emerging as an important target in anti-cancer drug discovery. In the present stud...
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Article
Open AccessNon-benzoquinone geldanamycin analogs trigger various forms of death in human breast cancer cells
Hsp90 proteins are important therapeutic targets for many anti-cancer drugs in clinical trials. Geldanamycin (GA) was identified as the first natural inhibitor of Hsp90, increasing evidence suggests that GA wa...
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Article
Enzymatic synthesis of novel isobavachalcone glucosides via a UDP-glycosyltransferase
Glycosylation is often used to improve a natural product’s properties such as water solubility, chemical stability, pharmacological potency, and structure diversification. In this study, we studied the enzyma...
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Article
A new dimeric neolignan from Magnolia grandiflora L. seeds
Bioassay-guided fractionation of the MeOH extract of Magnolia grandiflora seeds resulted in the isolation of a new dimeric neolignan, named bishonokiol A (1), as well as two known neolignans magnolol (2) and hono...
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Article
Biosynthesis of plant-specific phenylpropanoids by construction of an artificial biosynthetic pathway in Escherichia coli
Biological synthesis of plant secondary metabolites has attracted increasing attention due to their proven or assumed beneficial properties and health-promoting effects. Phenylpropanoids are the precursors to ...
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Article
New non-quinone geldanamycin analogs from genetically engineered Streptomyces hygroscopicus
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Article
6-alkylsalicylic acid analogues inhibit in vitro ATPase activity of heat shock protein 90
The molecular chaperone heat shock protein 90 (Hsp90) is responsible for maintaining the correct folding and stability of many signaling proteins. It is a promising target of cancer therapeutics and several ot...
