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  1. Article

    Open Access

    Application of deep learning to predict the low serum albumin in new hemodialysis patients

    Serum albumin level is a crucial nutritional indicator for patients on dialysis. Approximately one-third of patients on hemodialysis (HD) have protein malnutrition. Therefore, the serum albumin level of patien...

    Cheng-Hong Yang, Yin-Syuan Chen, **-Bor Chen, Hsiu-Chen Huang in Nutrition & Metabolism (2023)

  2. Article

    Open Access

    Association of proportion of the HDL-cholesterol subclasses HDL-2b and HDL-3 and macrovascular events among patients undergoing hemodialysis

    Altered high-density lipoprotein cholesterol (HDL-C) subclass distribution in hemodialysis (HD) patients is well documented. Aim of this study is to investigate the relationship between HDL-C subclass distribu...

    Wen-Chin Lee, **-Bor Chen, Sin-Hua Moi, Cheng-Hong Yang in Scientific Reports (2021)

  3. No Access

    Article

    Importance of non-medical reasons for dropout in patients on peritoneal dialysis

    To describe the associated factors for non-medical reasons for dropout in peritoneal dialysis (PD) patients.

    Lin Zhang, Wen-Chin Lee, Chien-Hsing Wu in Clinical and Experimental Nephrology (2020)

  4. Article

    Open Access

    Time-varying serum albumin levels and all-cause mortality in prevalent peritoneal dialysis patients: a 5-year observational study

    In this study, we investigated the association of time-varying serum albumin levels with mortality over a 5-year period in one cohort of patients undergoing long-term peritoneal dialysis (PD) therapy.

    Na Hao, Ben-Chung Cheng, Hong-Tao Yang, Chien-Hsing Wu, Yang-Yang Lei in BMC Nephrology (2019)

  5. No Access

    Chapter and Conference Paper

    Improved Classification Method for Detecting Potential Interactions Between Genes

    Multifactor dimensionality reduction (MDR) constitutes a highly accurate classification algorithm for gene–gene interaction (GGI) identification. GGI detection quality is commonly assessed using the correct cl...

    Li-Yeh Chuang, Yu-Da Lin, Cheng-Hong Yang in Intelligent Computing (2019)

  6. Chapter and Conference Paper

    The Service Design of Medication Administration System Based on IoT

    Medication is the most common way for patients to combat illness, and following the doctor’s advice on taking medication has a tremendous impact on a patient’s healing speed. But due to a variety of conditions...

    **u Fan Yang, Zhen Yu Gu, Rong Jiang in HCI International 2019 – Late Breaking Pos… (2019)

  7. No Access

    Chapter and Conference Paper

    An Improved Multi-factor Dimensionality Reduction Approach to Identify Gene-Gene Interactions

    Genetic component of disease risk can be determined by gene–gene interactions. Multifactor dimensionality reduction (MDR) has widely used to identify gene–gene interactions based on the binary classification i...

    Li-Yeh Chuang, Yu-Da Lin, Cheng-Hong Yang in Advances in Intelligent, Interactive Syste… (2019)

  8. Article

    Open Access

    Protein folding prediction in the HP model using ions motion optimization with a greedy algorithm

    The function of a protein is determined by its native protein structure. Among many protein prediction methods, the Hydrophobic-Polar (HP) model, an ab initio method, simplifies the protein folding prediction ...

    Cheng-Hong Yang, Kuo-Chuan Wu, Yu-Shiun Lin, Li-Yeh Chuang in BioData Mining (2018)

  9. Article

    Open Access

    Longitudinal analysis of cardiac structure and function in incident-automated peritoneal dialysis: comparison between icodextrin solution and glucose-based solution

    This study aimed to evaluate the longitudinal changes in cardiac structure and function in incident-automated peritoneal dialysis (APD) patients.

    **-Bor Chen, Ben-Chung Cheng, Wen-Hao Liu, Shang-Chih Liao in BMC Nephrology (2018)

  10. Article

    Open Access

    Cumulative receiver operating characteristics for analyzing interaction between tissue visfatin and clinicopathologic factors in breast cancer progression

    Visfatin has been reported to be associated with breast cancer progression, but the interaction between the visfatin and clinicopathologic factors in breast cancer progression status requires further investiga...

    Sin-Hua Moi, Yi-Chen Lee, Li-Yeh Chuang, Shyng-Shiou F. Yuan in Cancer Cell International (2018)

  11. Article

    Open Access

    Impact of risk factors on functional status in maintenance hemodialysis patients

    To survey by measuring patient’s functional status which is crucial when end-stage renal disease patients begin a dialysis program. The influence of the disease on patients can be examined by the measurement o...

    **-Bor Chen, Wen-Chin Lee, Ben-Chung Cheng in European Journal of Medical Research (2017)

  12. Article

    Open Access

    Publisher Correction: Multiobjective differential evolution-based multifactor dimensionality reduction for detecting gene–gene interactions

     A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.

    Cheng-Hong Yang, Li-Yeh Chuang, Yu-Da Lin in Scientific Reports (2017)

  13. Article

    Open Access

    Multiobjective differential evolution-based multifactor dimensionality reduction for detecting gene–gene interactions

    Epistasis within disease-related genes (gene–gene interactions) was determined through contingency table measures based on multifactor dimensionality reduction (MDR) using single-nucleotide polymorphisms (SNPs...

    Cheng-Hong Yang, Li-Yeh Chuang, Yu-Da Lin in Scientific Reports (2017)

  14. Article

    Open Access

    MicroRNA-122 as a predictor of HBsAg seroclearance in hepatitis B and C dual infected patients treated with interferon and ribavirin

    It has been demonstrated that microRNA-122 (miR-122) plays key roles in the modulation of hepatitis B virus (HBV) replication. This study examined the role of miR-122 in patients with hepatitis C virus (HCV)-H...

    Yi-Hao Yen, Chao-Min Huang, Kuo-Liang Wei, **g-Houng Wang in Scientific Reports (2016)

  15. Article

    Open Access

    An association between time-varying serum albumin level and the mortality rate in maintenance haemodialysis patients: a five-year clinical cohort study

    Until now, no long-term studies relating serum albumin level to mortality rate in prevalent haemodialysis (HD) patients have been conducted. We aimed to examine the association between serum albumin level and ...

    **-Bor Chen, Ben-Chung Cheng, Cheng-Hong Yang, Moi-Sin Hua in BMC Nephrology (2016)

  16. Article

    Open Access

    An efficiency analysis of high-order combinations of gene–gene interactions using multifactor-dimensionality reduction

    Multifactor dimensionality reduction (MDR) is widely used to analyze interactions of genes to determine the complex relationship between diseases and polymorphisms in humans. However, the astronomical number o...

    Cheng-Hong Yang, Yu-Da Lin, Cheng-San Yang, Li-Yeh Chuang in BMC Genomics (2015)

  17. Article

    Open Access

    Identification of SNP barcode biomarkers for genes associated with facial emotion perception using particle swarm optimization algorithm

    Facial emotion perception (FEP) can affect social function. We previously reported that parts of five tested single-nucleotide polymorphisms (SNPs) in the MET and AKT1 genes may individually affect FEP perform...

    Li-Yeh Chuang, Hsien-Yuan Lane, Yu-Da Lin, Ming-Teng Lin in Annals of General Psychiatry (2014)

  18. Article

    Open Access

    Identifying association model for single-nucleotide polymorphisms of ORAI1 gene for breast cancer

    ORAI1 channels play an important role for breast cancer progression and metastasis. Previous studies indicated the strong correlation between breast cancer and individual single nucleotide polymorphisms (SNPs) of...

    Wei-Chiao Chang, Yong-Yuan Fang, Hsueh-Wei Chang in Cancer Cell International (2014)

  19. No Access

    Article

    Specific primer design for the polymerase chain reaction

    The design of primers has a major impact on the success of PCR in relation to the specificity and yield of the amplified product. Here, we introduce the applications of PCR as well as the definition and charac...

    Li-Yeh Chuang, Yu-Huei Cheng, Cheng-Hong Yang in Biotechnology Letters (2013)

  20. No Access

    Article

    Particle swarm optimization algorithm for analyzing SNP–SNP interaction of renin-angiotensin system genes against hypertension

    Most non-significant individual single nucleotide polymorphisms (SNPs) were undiscovered in hypertension association studies. Their possible SNP–SNP interactions were usually ignored and leaded to missing heri...

    Shyh-Jong Wu, Li-Yeh Chuang, Yu-Da Lin, Wen-Hsien Ho in Molecular Biology Reports (2013)

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