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Article
Open AccessThe secreted peptide BATSP1 promotes thermogenesis in adipocytes
Although brown adipose tissue (BAT) has historically been viewed as a major site for energy dissipation through thermogenesis, its endocrine function has been increasingly recognized. However, the circulating ...
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Article
Human milk-derived extracellular vesicles alleviate high fat diet-induced non-alcoholic fatty liver disease in mice
Nonalcoholic fatty liver disease (NAFLD), characterized by excessive hepatic lipid accumulation, imposes serious challenges on public health worldwide. Breastfeeding has been reported to reduce the risk of NAF...
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Article
Open AccessVitamin B12 status and folic acid/vitamin B12 related to the risk of gestational diabetes mellitus in pregnancy: a systematic review and meta-analysis of observational studies
This review was conducted to investigate the association between serum vitamin B12 levels as well as folic acid/vitamin B12 during pregnancy and the risk of gestational diabetes mellitus (GDM).
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Article
Changes in weight and height among Chinese preschool children during COVID-19 school closures
COVID-19-related school closures may increase the prevalence of childhood obesity, which has aroused public concerns. We aimed to analyze the weight and height changes in Chinese preschool children during the ...
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Article
Open AccessPeptidome analysis of umbilical cord mesenchymal stem cell (hUC-MSC) conditioned medium from preterm and term infants
The therapeutic role of mesenchymal stem cells (MSCs) has been widely confirmed in several animal models of premature infant diseases. Micromolecule peptides have shown promise for the treatment of premature i...
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Article
Fluorometric determination of the CCAAT/enhancer binding protein alpha by using gold nanoparticles and a labeled protein-binding DNA
A method is described for the determination of the CCAAT/enhancer binding protein alpha (C/EBPα) which is a regulator in adipocyte differentiation. The method is based on quenching of the red fluorescence (wit...
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Article
The clinical potential of circulating microRNAs in obesity
Obesity is a complex condition that is characterized by excessive fat accumulation, which can lead to the development of metabolic disorders, such as type 2 diabetes mellitus, nonalcoholic fatty liver disease ...
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Article
Open AccessAssociation of rs10830962 polymorphism with gestational diabetes mellitus risk in a Chinese population
To date, only three polymorphisms (rs10830962, rs7754840 and rs1470579) are included in the genome-wide association study Catalog (www.ebi.ac.uk/gwas). Howev...
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Article
Open AccessAssociation of maternal serum 25-hydroxyvitamin D concentrations in second and third trimester with risk of macrosomia
Whether the maternal vitamin D deficiency is associated with infant birth weight is still an argument. Here, we performed a nested case-control study (545 women who subsequently delivered infant with macrosomi...
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Article
Open AccessEvaluation and optimization of differentiation conditions for human primary brown adipocytes
As an effective way to improve energy expenditure, increasing the mass and activity of brown adipose tissue (BAT) has become a promising treatment for obesity and its associated disorders. Many efforts have be...
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Article
Open AccessThe effect of maternal vitamin D deficiency during pregnancy on body fat and adipogenesis in rat offspring
To evaluate the effects of maternal vitamin D deficiency on body fat and adipogenesis in offspring rats, and explore the potential mechanism, we constructed a vitamin D deficient rat model and performed metabo...
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Article
Association between maternal nonresponsive feeding practice and child’s eating behavior and weight status: children aged 1 to 6 years
The purposes of this study are to investigate the prevalence of nonresponsive feeding practice (NRFP) and child’s eating behavior (CEB) and to explore the hypothetical association between child’s weight status...
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Article
Open AccessInvestigation into the antimicrobial action and mechanism of a novel endogenous peptide β-casein 197 from human milk
A novel endogenous peptide cleaved from 197–213 AA of β-casein, named β-casein 197, was identified by tandem mass spectrometry. β-casein 197 constituted a significant proportion of the peptide content in prete...
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Article
Open AccessmiR-148a is Associated with Obesity and Modulates Adipocyte Differentiation of Mesenchymal Stem Cells through Wnt Signaling
Obesity results from numerous, interacting genetic, behavioral and physiological factors. Adipogenesis is partially regulated by several adipocyte-selective microRNAs (miRNAs) and transcription factors that re...
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Article
Differential lncRNA expression profiles in brown and white adipose tissues
Long non-coding RNAs (lncRNAs) are an important class of pervasive genes involved in a variety of biological functions. It can serve as key co-activators of proteins involved in transcriptional regulation. Stu...
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Article
MiR-335, an Adipogenesis-Related MicroRNA, is Involved in Adipose Tissue Inflammation
During the development of obesity, adipose tissue releases a host of different adipokines and inflammatory cytokines, such as leptin, resistin, tumor necrosis factor α (TNF-α), Interleukin-6 (IL-6), and adipon...
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Article
FFAs and adipokine-mediated regulation of hsa-miR-143 expression in human adipocytes
Accumulating evidence suggests that microRNAs (miRNAs) play an important role in regulating the pathways in adipose tissue that control processes such as adipogenesis, insulin resistance, and inflammation. MiR...
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Article
A Novel pro-adipogenesis factor abundant in adipose tissues and over-expressed in obesity acts upstream of PPARγ and C/EBPα
An important question about adipogenesis is how master adipogenesis factors (defined as being able to initiate adipogenesis when expressed alone) peroxisome proliferator-activated receptor (PPAR) initiate adip...
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Article
Modulation of hsa-miR-26b levels following adipokine stimulation
MicroRNAs (miRNAs) are short non-coding RNAs that are involved in post-transcriptional regulation of gene expression. Hsa-miR-26b is an intronic miRNA located in the intron of CTDSP1 (carboxy-terminal domain, RNA...
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Article
IL-6 induces lipolysis and mitochondrial dysfunction, but does not affect insulin-mediated glucose transport in 3T3-L1 adipocytes
Interleukin-6 (IL-6) has emerged as an important cytokine involved in the regulation of metabolism. However, the role of IL-6 in the etiology of obesity and insulin resistance is not fully understood. Mitochon...
