58 Result(s)

Article

Caspase-3 promotes oncogene-induced malignant transformation via EndoG-dependent Src-STAT3 phosphorylation

Accumulating evidence suggests that caspase-3 plays critical roles beyond apoptosis, serving pro-survival functions in malignant transformation and tumorigenesis. However, the mechanism of non-apoptotic action...

Chenchen Zhu, Fushun Fan, Chuan-Yuan Li, Yan **ong, **njian Liu in Cell Death & Disease (2024)

Article

RANKL/RANK signaling recruits Tregs via the CCL20–CCR6 pathway and promotes stemness and metastasis in colorectal cancer

TNF receptor superfamily member 11a (TNFRSF11a, RANK) and its ligand TNF superfamily member 11 (TNFRSF11, RANKL) are overexpressed in many malignancies. However, the clinical importance of RANKL/RANK in colore...

**g Ouyang, Shuang Hu, Qingqing Zhu, Chenxin Li, Tingting Kang… in Cell Death & Disease (2024)

Article

TMC6 functions as a GPCR-like receptor to sense noxious heat via Gαq signaling

Thermosensation is vital for the survival, propagation, and adaption of all organisms, but its mechanism is not fully understood yet. Here, we find that TMC6, a membrane protein of unknown function, is highly ...

Chen Zhang, Fang Tong, Bin Zhou, Mingdong He, Shuai Liu, **aomeng Zhou… in Cell Discovery (2024)

Article

HNF4α ubiquitination mediated by Peli1 impairs FAO and accelerates pressure overload-induced myocardial hypertrophy

Impaired fatty acid oxidation (FAO) is a prominent feature of metabolic remodeling observed in pathological myocardial hypertrophy. Hepatocyte nuclear factor 4alpha (HNF4α) is closely associated with FAO in bo...

Yuxing Hou, Pengxi Shi, Haiyang Du, Chenghao Zhu, Chao Tang… in Cell Death & Disease (2024)

Article

Tumor microenvironment remodeling plus immunotherapy could be used in mesenchymal-like tumor with high tumor residual and drug resistant rate

Epithelial-mesenchymal transition (EMT) is a common process during tumor progression and is always related to residual tumor, drug resistance and immune suppression. However, considering the heterogeneity in E...

Shuai Shen, **ng Liu, Qing Guo, Qingyu Liang, Jianqi Wu… in Communications Biology (2023)

Article

Droplet-based single-cell joint profiling of histone modifications and transcriptomes

We previously reported Paired-Tag, a combinatorial indexing-based method that can simultaneously map histone modifications and gene expression at single-cell resolution at scale. However, the lengthy procedure...

Yang **e, Chenxu Zhu, Zhaoning Wang… in Nature Structural & Molecular Biology (2023)

Article

Bacterial coinfections contribute to severe COVID-19 in winter

Hui Fan, Li Zhou, **gjun Lv, Shimin Yang, Guozhong Chen, **n** Liu… in Cell Research (2023)

Article

Privacy-preserving integration of multiple institutional data for single-cell type identification with scPrivacy

The rapid accumulation of large-scale single-cell RNA-seq datasets from multiple institutions presents remarkable opportunities for automatically cell annotations through integrative analyses. However, the pri...

Shaoqi Chen, Bin Duan, Chenyu Zhu, Chen Tang, Shuguang Wang… in Science China Life Sciences (2023)

Article

Tyrosine kinase SRC-induced YAP1-KLF5 module regulates cancer stemness and metastasis in triple-negative breast cancer

SRC is the first identified oncogene, and its aberrant activation has been implicated as a driving event in tumor initiation and progression. However, its role in cancer stemness regulation and the underlying ...

Hailin Zou, Juan Luo, Yibo Guo, Tongyu Tong… in Cellular and Molecular Life Sciences (2023)

Article

COVID-19 vaccination boosts the potency and breadth of the immune response against SARS-CoV-2 among recovered patients in Wuhan

The immunity of patients who recover from coronavirus disease 2019 (COVID-19) could be long lasting but persist at a lower level. Thus, recovered patients still need to be vaccinated to prevent reinfection by ...

Hong Liang, Xuanxuan Nian, Junzheng Wu, Dong Liu, Lu Feng, Jia Lu… in Cell Discovery (2022)

Article

Plant-frugivore network simplification under habitat fragmentation leaves a small core of interacting generalists

Habitat fragmentation impacts seed dispersal processes that are important in maintaining biodiversity and ecosystem functioning. However, it is still unclear how habitat fragmentation affects frugivorous inter...

Wande Li, Chen Zhu, Ingo Grass, Diego P. Vázquez, Duorun Wang… in Communications Biology (2022)

Article

Single-cell epigenome analysis reveals age-associated decay of heterochromatin domains in excitatory neurons in the mouse brain

Loss of heterochromatin has been implicated as a cause of pre-mature aging and age-associated decline in organ functions in mammals; however, the specific cell types and gene loci affected by this type of epig...

Yanxiao Zhang, Maria Luisa Amaral, Chenxu Zhu, Steven Francis Grieco… in Cell Research (2022)

Article

Mutagenesis of the odorant receptor co-receptor (Orco) reveals severe olfactory defects in the crop pest moth Helicoverpa armigera

Odorant receptors (ORs) as odorant-gated ion channels play a crucial role in insect olfaction. They are formed by a heteromultimeric complex of the odorant receptor co-receptor (Orco) and a ligand-selective Or...

**ao-Bin Fan, Bao-Tong Mo, Guo-Cheng Li, Ling-Qiao Huang, Hao Guo… in BMC Biology (2022)

Article

ABAT gene expression associated with the sensitivity of hypomethylating agents in myelodysplastic syndrome through CXCR4/mTOR signaling

The factors that affect hypomethylating agents (HMAs) sensitivity in myelodysplastic syndrome (MDS) are complex and multifaceted. They include DNA methylation, gene expression, mutation, etc. However, the unde...

Guangjie Zhao, Shuang Li, Qian Wang, Wanlin Wu, Xuewei Fu, Chen Zhu… in Cell Death Discovery (2022)

Article

Correction to: BMP9 reduces age-related bone loss in mice by inhibiting osteoblast senescence through Smad1-Stat1-P21 axis

**g-zun Xu, Yan-man Zhou, Lin-lin Zhang, **ao-**g Chen… in Cell Death Discovery (2022)