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Article
Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms
Smc5/6 is a member of the eukaryotic structural maintenance of chromosomes (SMC) family of complexes with important roles in genome maintenance and viral restriction. However, limited structural understanding ...
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Article
Open AccessSingle-cell analysis of chromatin accessibility in the adult mouse brain
Recent advances in single-cell technologies have led to the discovery of thousands of brain cell types; however, our understanding of the gene regulatory programs in these cell types is far from complete1–4. Here...
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Article
Open AccessDroplet-based single-cell joint profiling of histone modifications and transcriptomes
We previously reported Paired-Tag, a combinatorial indexing-based method that can simultaneously map histone modifications and gene expression at single-cell resolution at scale. However, the lengthy procedure...
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Chapter and Conference Paper
A Microservice-Based Visual Orchestration Platform for 5G IoT Applications
Nowadays, with the increasing sensors in the fifth generation (5G) cellular network and Internet of Thing (IoT), data interaction gains much attention. Through collecting and analyzing the surrounding environm...
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Chapter and Conference Paper
5G Close Loop Proactive Optimization Using Network Data Analysis Function
With the operational expenditure (OPEX) rising sharply, the 5G/B5G network architecture introduces endogenous intelligent data analysis network function to achieve more automated operations and optimizations. ...
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Chapter and Conference Paper
Research of Voice Speech Quality Evaluation Based on Trace Data
With the gradual increase of users’ expectation for the cellular network, the evaluation of voice quality changes from the network management to the assurance mechanism focusing on the customer perception. In ...
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Chapter and Conference Paper
5G Construction Efficiency Enhancement Based on LSTM Algorithm
Improving the 5G resident ratio becomes one of the essential tasks of network operation in the period of high-speed development of 5G. This paper introduces a 5G construction efficiency evaluation method, whic...
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Protocol
Single-Cell Joint Profiling of Open Chromatin and Transcriptome by Paired-Seq
Simultaneous detection of chromatin accessibility and transcription from the same cells promises to greatly facilitate the dissection of cell-type-specific gene regulatory programs in complex tissues. Paired-s...
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Article
Open AccessThe molecular mechanism of cytoadherence to placental or tumor cells through VAR2CSA from Plasmodium falciparum
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Article
Open AccessEpigenetic regulation of covalently closed circular DNA minichromosome in hepatitis B virus infection
Hepatitis B is caused by hepatitis B virus (HBV), and persistent HBV infection is a global public health problem, with 257 million people as HBV chronic carriers. Viral covalently closed circular DNA (cccDNA) ...
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Article
A calcineurin–Hoxb13 axis regulates growth mode of mammalian cardiomyocytes
A major factor in the progression to heart failure in humans is the inability of the adult heart to repair itself after injury. We recently demonstrated that the early postnatal mammalian heart is capable of r...
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Chapter and Conference Paper
A Web-Component-Based Cross-Platform Mobile Application Development Environment for Ordinary Users
The rapid progress of the mobile internet has been promoting the popularity of mobile devices, and mobile application development is getting more pervasive. However, state of the art development environments ...
