4 Result(s)
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Chanjuan Shi
Biomedicine
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Article
Open AccessACAA2 is a novel molecular indicator for cancers with neuroendocrine phenotype
Neuroendocrine phenotype is commonly associated with therapy resistance and poor prognoses in small-cell neuroendocrine cancers (SCNCs), such as neuroendocrine prostate cancer (NEPC) and small-cell lung cancer...
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Article
A case report of clonal EBV-like memory CD4+ T cell activation in fatal checkpoint inhibitor-induced encephalitis
Checkpoint inhibitors produce durable responses in numerous metastatic cancers, but immune-related adverse events (irAEs) complicate and limit their benefit. IrAEs can affect organ systems idiosyncratically; p...
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Article
A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors
We introduce and validate a new precision oncology framework for the systematic prioritization of drugs targeting mechanistic tumor dependencies in individual patients. Compounds are prioritized on the basis o...
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Protocol
Patch-Clamp Recording Methods for Examining Adrenergic Regulation of Potassium Currents in Ocular Epithelial Cells
Neurotransmitters act on cell-surface receptors to produce a wide range of effects on target cells (1). These effects include modulation of ion channels and changes in cellular electrical properties. Deciphering ...
