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Article
Open AccessMolecular and clinicopathologic characteristics of CNS embryonal tumors with BRD4::LEUTX fusion
Central nervous system (CNS) embryonal tumors are a heterogeneous group of high-grade malignancies, and the increasing clinical use of methylation profiling and next-generation sequencing has led to the identi...
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Article
Open AccessACAA2 is a novel molecular indicator for cancers with neuroendocrine phenotype
Neuroendocrine phenotype is commonly associated with therapy resistance and poor prognoses in small-cell neuroendocrine cancers (SCNCs), such as neuroendocrine prostate cancer (NEPC) and small-cell lung cancer...
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Article
Crosstalk between small-cell lung cancer cells and astrocytes mimics brain development to promote brain metastasis
Brain metastases represent an important clinical problem for patients with small-cell lung cancer (SCLC). However, the mechanisms underlying SCLC growth in the brain remain poorly understood. Here, using intra...
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Article
A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk
The human brain vasculature is of great medical importance: its dysfunction causes disability and death1, and the specialized structure it forms—the blood–brain barrier—impedes the treatment of nearly all brain d...
