Skip to main content

3 Result(s)

within Chad A. Brautigam Remove this filter Science, Humanities and Social Sciences, multidisciplinary Remove this filter English Remove this filter

and

  1. Article

    Open Access

    Mechanism of karyopherin-β2 binding and nuclear import of ALS variants FUS(P525L) and FUS(R495X)

    Mutations in the RNA-binding protein FUS cause familial amyotropic lateral sclerosis (ALS). Several mutations that affect the proline-tyrosine nuclear localization signal (PY-NLS) of FUS cause severe juvenile ...

    Abner Gonzalez, Taro Mannen, Tolga Çağatay, Ayano Fujiwara… in Scientific Reports (2021)

    Download PDF (6992 KB) View Article

  2. Article

    Open Access

    Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing

    The spindle checkpoint maintains genomic stability and prevents aneuploidy. Unattached kinetochores convert the latent open conformer of the checkpoint protein Mad2 (O-Mad2) to the active closed conformer (C-M...

    Melissa L. Brulotte, Byung-Cheon Jeong, Faxiang Li, Bing Li… in Nature Communications (2017)

    Download PDF (2868 KB) View Article

  3. Article

    Open Access

    Structural basis of arrestin-3 activation and signaling

    A unique aspect of arrestin-3 is its ability to support both receptor-dependent and receptor-independent signaling. Here, we show that inositol hexakisphosphate (IP6) is a non-receptor activator of arrestin-3 and...

    Qiuyan Chen, Nicole A. Perry, Sergey A. Vishnivetskiy… in Nature Communications (2017)

    Download PDF (2276 KB) View Article