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Article

Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing

The spindle checkpoint maintains genomic stability and prevents aneuploidy. Unattached kinetochores convert the latent open conformer of the checkpoint protein Mad2 (O-Mad2) to the active closed conformer (C-M...

Melissa L. Brulotte, Byung-Cheon Jeong, Faxiang Li, Bing Li… in Nature Communications (2017)