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Publisher Correction: G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3
The adhesion G-protein-coupled receptor (GPCR) latrophilin 3 (ADGRL3) has been associated with increased risk of attention deficit hyperactivity disorder (ADHD) and substance use in human genetic studies. Knoc...
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Using In Vitro Pull-Down and In-Cell Overexpression Assays to Study Protein Interactions with Arrestin
Nonvisual arrestins (arrestin-2/arrestin-3) interact with hundreds of G protein-coupled receptor (GPCR) subtypes and dozens of non-receptor signaling proteins. Here we describe the methods used to identify the...
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Open AccessStructural basis of arrestin-3 activation and signaling
A unique aspect of arrestin-3 is its ability to support both receptor-dependent and receptor-independent signaling. Here, we show that inositol hexakisphosphate (IP6) is a non-receptor activator of arrestin-3 and...
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Open Accessβ-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions
β-arrestins are critical signalling molecules that regulate many fundamental physiological functions including the maintenance of euglycemia and peripheral insulin sensitivity. Here we show that inactivation o...
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Monofunctional Elements of Multi-functional Proteins
Arrestins can act as activators or molecular for various effectors, including signaling cascades, clathrin and AP2, E3 ubiquitin ligases, and phosphatases. Current investigations have focused on isolating ...
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Open AccessPeptide mini-scaffold facilitates JNK3 activation in cells
Three-kinase mitogen-activated protein kinase (MAPK) signaling cascades are present in virtually all eukaryotic cells. MAPK cascades are organized by scaffold proteins, which assemble cognate kinases into prod...
