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Open AccessPersistent symptoms after COVID-19 are not associated with differential SARS-CoV-2 antibody or T cell immunity
Among the unknowns in decoding the pathogenesis of SARS-CoV-2 persistent symptoms in Long Covid is whether there is a contributory role of abnormal immunity during acute infection. It has been proposed that Lo...
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Open AccessCOVID-19 vaccine boosted immunity against Omicron in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors
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Open AccessAntibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab
Anti tumour necrosis factor (anti-TNF) drugs increase the risk of serious respiratory infection and impair protective immunity following pneumococcal and influenza vaccination. Here we report SARS-CoV-2 vaccin...
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Open AccessComparative systematic review and meta-analysis of reactogenicity, immunogenicity and efficacy of vaccines against SARS-CoV-2
As SARS-CoV-2 vaccines are deployed worldwide, a comparative evaluation is important to underpin decision-making. We here report a systematic literature review and meta-analysis of Phase I/II/III human trials ...
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The METROPOLE Project – An Integrated Framework to Analyse Local Decision Making and Adaptive Capacity to Large-Scale Environmental Change: Decision Making and Adaptation to Sea Level Rise in Santos, Brazil
Assessment of the risks due to exposure and sensitivity of coastal communities to coastal flooding is essential for informed decision-making. Strategies for public understanding and awareness of the tangible e...
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Immunology of the Microbiome: Implications for Rheumatoid Arthritis and Other Autoimmune Diseases
In rheumatoid arthritis, as in many other autoimmune and inflammatory conditions, there is considerable interest in the accruing evidence that pathogenesis may involve downstream consequences of microbiota dys...
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Article
Open AccessInfection with Burkholderia pseudomallei – immune correlates of survival in acute melioidosis
Melioidosis, caused by Burkholderia pseudomallei, is a potentially lethal infection with no licensed vaccine. There is little understanding of why some exposed individuals have no symptoms, while others rapidly p...
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A globally deployable strategy for co-development of adaptation preferences to sea-level rise: the public participation case of Santos, Brazil
Sea-level rise (SLR) poses a range of threats to natural and built environments in coastal zones around the world. Assessment of the risks due to exposure and sensitivity of coastal communities to coastal floo...
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Article
Open AccessAutoantigen cross-reactive environmental antigen can trigger multiple sclerosis-like disease
Multiple sclerosis is generally considered an autoimmune disease resulting from interaction between predisposing genes and environmental factors, together allowing immunological self-tolerance to be compromise...
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Article
Open AccessNatural cutaneous anthrax infection, but not vaccination, induces a CD4+ T cell response involving diverse cytokines
Whilst there have been a number of insights into the subsets of CD4+ T cells induced by pathogenic Bacillus anthracis infections in animal models, how these findings relate to responses generated in naturally inf...