10 Result(s)
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Carly G. K. Ziegler
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Open AccessPublisher Correction: Live cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes
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Open AccessLive cell tagging tracking and isolation for spatial transcriptomics using photoactivatable cell dyes
A cell’s phenotype and function are influenced by dynamic interactions with its microenvironment. To examine cellular spatiotemporal activity, we developed SPACECAT—Spatially PhotoActivatable Color Encoded Cel...
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COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets
COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress syndrome and multiple organ failure1–4, but little is known about its pathophysiology. Here we generated single-cell atlases of 24...
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Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics
Angiotensin-converting enzyme 2 (ACE2) and accessory proteases (TMPRSS2 and CTSL) are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular entry, and their expression may shed light...
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Open AccessIntegrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection
Cellular immunity is critical for controlling intracellular pathogens, but individual cellular dynamics and cell–cell cooperativity in evolving human immune responses remain poorly understood. Single-cell RNA-...
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Open AccessSelective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses
Mice engrafted with components of a human immune system have become widely-used models for studying aspects of human immunity and disease. However, a defined methodology to objectively measure and compare the ...
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Open AccessMultiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction
We present a scalable, integrated strategy for coupled protein and RNA detection from single cells. Our approach leverages the DNA polymerase activity of reverse transcriptase to simultaneously perform proximi...
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Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis
This work identifies a role for intestinal epithelial cell (IEC)-intrinsic expression of histone deacetylase 3 in regulating commensal-bacteria-dependent gene expression and intestinal homeostasis; IEC-specifi...
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Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria
Group 3 innate lymphoid cells are shown to process and present antigen and to control CD4+ T-cell responses to intestinal commensal bacteria through an MHC-class-II-dependent mechanism.
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Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
Cytokine-producing innate lymphoid cells are found at mucosal surfaces. Artis and Wherry and their colleagues show that innate 'nuocyte-like' cells accumulate in virus-infected lungs and contribute to the repa...
