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Article
Open AccessSpecificity, synergy, and mechanisms of splice-modifying drugs
Drugs that target pre-mRNA splicing hold great therapeutic potential, but the quantitative understanding of how these drugs work is limited. Here we introduce mechanistically interpretable quantitative models ...
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Article
Open AccessDesigned active-site library reveals thousands of functional GFP variants
Mutations in a protein active site can lead to dramatic and useful changes in protein activity. The active site, however, is sensitive to mutations due to a high density of molecular interactions, substantiall...
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Article
Functional Impact and Regulation of Alternative Splicing in Mouse Heart Development and Disease
Alternative splicing (AS) plays a major role in the generation of transcript diversity. In the heart, roles have been described for some AS variants, but the global impact and regulation of AS patterns are poo...
