7 Result(s)
within
Cam Patterson
Biomedicine
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Article
Bone Morphogenetic Protein-Modulator BMPER Regulates Endothelial Barrier Function
The endothelium serves as a selective barrier and controls the exchange of nutrients, hormones, and leukocytes between blood and tissues. Molecular mechanisms contributing to the pathogenesis of endothelial ba...
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Article
Open AccessEmerging evidence of coding mutations in the ubiquitin–proteasome system associated with cerebellar ataxias
Cerebellar ataxia (CA) is a disorder associated with impairments in balance, coordination, and gait caused by degeneration of the cerebellum. The mutations associated with CA affect functionally diverse genes;...
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Article
Open AccessAnkyrin repeat and SOCS box containing protein 4 (Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the hypothalamic neurons and mediates IRS4 degradation
The arcuate nucleus of the hypothalamus regulates food intake. Ankyrin repeat and SOCS box containing protein 4 (Asb-4) is expressed in neuropeptide Y and proopiomelanocortin (POMC) neurons in the arcuate nucl...
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Article
Torturing a blood vessel
Experiments in mice and zebrafish uncover a pathway behind malformed blood vessels in the brain (pages 169–176 & 177–184
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Chapter
The Role of Thrombin in Vascular Development
Vasculogenesis is essential for embryonic development. The vasculature and the intravascular blood compartment develop in a close spatial and temporal relationship. Here we discuss how thrombin, as the common ...
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Article
Open AccessTobacco use induces anti-apoptotic, proliferative patterns of gene expression in circulating leukocytes of Caucasian males
Strong epidemiologic evidence correlates tobacco use with a variety of serious adverse health effects, but the biological mechanisms that produce these effects remain elusive.
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Article
Shear Stress Reduces Protease Activated Receptor-1 Expression in Human Endothelial Cells
Shear stress has been shown to regulate several genes involved in the thrombotic and proliferative functions of endothelial cells. Thrombin receptor (protease-activated receptor-1: PAR-1) increases at sites of...
