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Article
Open AccessMonocyte subset distribution and surface expression of HLA-DR and CD14 in patients after cardiopulmonary resuscitation
Systemic inflammation is a major feature of the post-cardiac arrest syndrome. The three monocyte subpopulations are thought to play an important role in this inflammatory state because they are endowed with nu...
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Article
Open AccessA DARPin targeting activated Mac-1 is a novel diagnostic tool and potential anti-inflammatory agent in myocarditis, sepsis and myocardial infarction
The monocyte β2-integrin Mac-1 is crucial for leukocyte–endothelium interaction, rendering it an attractive therapeutic target for acute and chronic inflammation. Using phage display, a Designed-Ankyrin-Repeat-Pr...
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Article
Endothelial BMP4 Promotes Leukocyte Rolling and Adhesion and Is Elevated in Patients After Survived Out-of-Hospital Cardiac Arrest
Leukocyte recruitment is a fundamental step in the inflammatory response during ischemia/reperfusion injury (IRI). Rolling and adhesion of leukocytes to activated endothelium promote tissue inflammation after ...
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Article
Prospective evaluation of the quickSOFA score as a screening for sepsis in the emergency department
In 2016, the new bedside tool quick Sequential (Sepsis-related) Organ Failure Assessment (qSOFA) was presented to identify patients at high risk of develo** sepsis or adverse outcome. The aim of this study w...
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Article
Semaphorin 3F Promotes Transendothelial Migration of Leukocytes in the Inflammatory Response After Survived Cardiac Arrest
Leukocyte transmigration through the blood vessel wall is a fundamental step of the inflammatory response and requires expression of adhesion molecule PECAM-1. Accumulating evidence implicates that semaphorin ...
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Article
Chip-based digital PCR as a novel detection method for quantifying microRNAs in acute myocardial infarction patients
miRNAs have shown promise as potential biomarkers for acute myocardial infarction (AMI). However, the current used quantitative real-time PCR (qRT-PCR) allows solely for relative expression of nucleic acids an...
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Article
Endothelial BMP4 Regulates Leukocyte Diapedesis and Promotes Inflammation
Leukocyte recruitment is a fundamental event in the response of the innate immune system to injury. This process is promoted in part by the opening of endothelial cell adherens junctions that allows leukocyte ...
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Article
Bone Morphogenetic Protein-Modulator BMPER Regulates Endothelial Barrier Function
The endothelium serves as a selective barrier and controls the exchange of nutrients, hormones, and leukocytes between blood and tissues. Molecular mechanisms contributing to the pathogenesis of endothelial ba...
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Article
Open AccessInflammasome and toll-like receptor signaling in human monocytes after successful cardiopulmonary resuscitation
Whole body ischemia-reperfusion injury (IRI) after cardiopulmonary resuscitation (CPR) induces a generalized inflammatory response which contributes to the development of post-cardiac arrest syndrome (PCAS). R...
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Article
Open AccessSelenium prevents microparticle-induced endothelial inflammation in patients after cardiopulmonary resuscitation
Microparticles are elevated in patients after successful cardiopulmonary resuscitation (CPR) and may play a role in the development of endothelial dysfunction seen in post-cardiac arrest syndrome (PCAS), a lif...
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Article
Open AccessCirculating annexin V positive microparticles in patients after successful cardiopulmonary resuscitation
Ischemia/reperfusion after cardiopulmonary resuscitation (CPR) induces systemic inflammatory response and activation of endothelium and coagulation, resulting in a post-cardiac arrest syndrome. We analysed cir...
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Article
Discontinuation of long term clopidogrel therapy induces platelet rebound hyperaggregability between 2 and 6 weeks post cessation
Stent thrombosis occurs frequently within the first weeks after cessation of longterm clopidogrel therapy. We investigated if rebound platelet hyperreactivity occurs to provide a mechanism for this clinical ob...
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Article
Increased platelet, leukocyte and endothelial microparticles predict enhanced coagulation and vascular inflammation in pulmonary hypertension
Pulmonary hypertension (PH) is associated with platelet activation, vascular inflammation and endothelial dysfunction leading to often life threatening thrombo-embolic complications. Microparticles (MPs) are c...
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Chapter
The Individualization of Travel – Customer Management via Website, Mobile and Social Media
The travel market and its package offers prove difficult for the highly individualized needs of its customers. The Internet can be very helpful in overcoming this dilemma. However, it is not machine intelligen...
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Article
Clopidogrel affects leukocyte dependent platelet aggregation by P2Y12 expressing leukocytes
Up to 30% of all patients who are treated with a coronary stent do not respond sufficiently to antiplatelet therapy. This condition results in an increased risk for thrombotic complications such as stent throm...
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Chapter
Das Ohr am Puls des Internets
Gerade touristische Anbieter sind recht schnell in der Umsetzung neuer digitaler Formate und Plattformen. Blogs und das gesamte Angebotsspektrum des Social Web wurden daher sehr früh in der Tourismusbranche di...
