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Open AccessDown-regulation of MKP-1 in hippocampus protects against stress-induced depression-like behaviors and neuroinflammation
Chronic stress is the primary environmental risk factor for major depressive disorder (MDD), and there is compelling evidence that neuroinflammation is the major pathomechanism linking chronic stress to MDD. M...
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Open AccessMarine fungal metabolite butyrolactone I prevents cognitive deficits by relieving inflammation and intestinal microbiota imbalance on aluminum trichloride-injured zebrafish
Mounting evidences indicate that oxidative stress, neuroinflammation, and dysregulation of gut microbiota are related to neurodegenerative disorders (NDs). Butyrolactone I (BTL-I), a marine fungal metabolite, ...
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Article
Design, synthesis, and biological evaluation of novel stachydrine derivatives as potent neuroprotective agents for cerebral ischemic stroke
Stachydrine is a natural product with multiple protective biological activities, including those involved in preventing cancer, ischemia, and cardiovascular disease. However, its use has been limited by low bi...
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Article
Dietary eicosapentaenoic acid normalizes hippocampal omega-3 and 6 polyunsaturated fatty acid profile, attenuates glial activation and regulates BDNF function in a rodent model of neuroinflammation induced by central interleukin-1β administration
Interleukin (IL)-1β can activate glial cells to trigger neuroinflammation and neurodegeneration. Lower omega (n)-3 polyunsaturated fatty acids (PUFAs) and lower n-3/n-6 PUFA ratios occur in the brain of patien...
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Better lab animal models for translational neuroscience research and CNS drug development
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'Stressing' rodent self-grooming for neuroscience research
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Toward Omics-Based, Systems Biomedicine, and Path and Drug Discovery Methodologies for Depression-Inflammation Research
Meta-analyses confirm that depression is accompanied by signs of inflammation including increased levels of acute phase proteins, e.g., C-reactive protein, and pro-inflammatory cytokines, e.g., interleukin-6. ...
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Erratum: Neurobiology of rodent self-grooming and its value for translational neuroscience
Nature Reviews Neuroscience 17, 45–59 (2016) This article was published without one of its supplementary information files (Supplementary information S6). This file has now been added online, and the article a...
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Article
Neurobiology of rodent self-grooming and its value for translational neuroscience
Self-grooming is an evolutionarily conserved complex innate behaviour that has a role in hygiene maintenance and other physiological functions. Self-grooming i...
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Article
The mechanism and application of bronze-bond diamond grinding wheel pulsed laser dressing based on phase explosion
This paper presents a theoretical analysis of the surface bond removal mechanism for bronze-bond diamond grinding wheels using a pulsed laser. For the first time, the existence of a phase explosion phenomenon ...
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Open AccessThe Marginal Division of the Striatum and Hippocampus Has Different Role and Mechanism in Learning and Memory
The memory function of the hippocampal formation (Hip) and the marginal division (MrD) of neostriatum was compared. Rats with bilateral lesions of the MrD either immediate or 24 h after training in Y-maze were...
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Open AccessAcute and subacute IL-1β administrations differentially modulate neuroimmune and neurotrophic systems: possible implications for neuroprotection and neurodegeneration
In Alzheimer’s disease, stroke and brain injuries, activated microglia can release proinflammatory cytokines, such as interleukin (IL)-1β. These cytokines may change astrocyte and neurotrophin functions, which...
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Article
Open AccessDepression and sickness behavior are Janus-faced responses to shared inflammatory pathways
It is of considerable translational importance whether depression is a form or a consequence of sickness behavior. Sickness behavior is a behavioral complex induced by infections and immune trauma and mediated...
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Article
Open AccessAn efficient approach to finding Siraitia grosvenorii triterpene biosynthetic genes by RNA-seq and digital gene expression analysis
Siraitia grosvenorii (Luohanguo) is an herbaceous perennial plant native to southern China and most prevalent in Guilin city. Its fruit contains a sweet, fleshy, edible pulp that is widely used in traditional Chi...
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Article
Lower serum cytokine levels in smokers than nonsmokers with chronic schizophrenia on long-term treatment with antipsychotics
Schizophrenia is associated with various abnormalities in the immune system. Suppression of inflammatory cytokines by cigarette smoke is well-established. The purpose of this study was to determine any differe...
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Article
Erratum: Omega-3 Fatty Acid Ethyl-Eicosapentaenoate Attenuates IL-1β-Induced Changes in Dopamine and Metabolites in the Shell of the Nucleus Accumbens: Involved with PLA2 Activity and Corticosterone Secretion
Correction to: Neuropsychopharmacology (2007) 32, 736–744. doi:10.1038/sj.npp.1301117 Following the online publication of this article, the authors noted errors in the abstract. The correct abstract is below. ...
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Article
Omega-3 Fatty Acid Ethyl-Eicosapentaenoate Attenuates IL-1β-Induced Changes in Dopamine and Metabolites in the Shell of the Nucleus Accumbens: Involved with PLA2 Activity and Corticosterone Secretion
Previously, we have reported that interleukin-1 β (IL-1) induces changes in dopaminergic (DA) and serotonergic systems in the core of nucleus accumbens (NAc). We have also demonstrated that n-3 fatty acid ethyl-e...
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Stress, Depression, and The Role of Cytokines
The concept of an inter-relationship between the psychological state of a depressed patient and the immune status can be traced back to Galen who, in 200 AD, suggested that melancholic women are more susceptib...
