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Article
Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis
Bone marrow-derived cells have important roles in cancer development and progression. Our previous studies demonstrated that murine bone marrow-derived myofibroblasts (BMFs) enhanced tumor growth. In this stud...
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Article
Predictive factors of rapidly progressive-interstitial lung disease in patients with clinically amyopathic dermatomyositis
Clinically amyopathic dermatomyositis (CADM) is a unique subset of dermatomyositis, showing a high incidence of lung involvements. The aim of this study is to identify risk factors, other than melanoma differe...
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Article
Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death
Blockade of fatty acid synthase (FASN), a key enzyme involved in de novo lipogenesis, results in robust death of ovarian cancer cells. However, known FASN inhibitors have proven to be poor therapeutic agents due ...
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Article
Activation of Akt signaling in prostate induces a TGFβ-mediated restraint on cancer progression and metastasis
Mutations in the PTEN tumor suppressor gene are found in a high proportion of human prostate cancers, and in mice, Pten deletion induces high-grade prostate intraepithelial neoplasia (HGPIN). However, progression...
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Article
Open AccessPotent anti-tumour activity of a novel conditionally replicating adenovirus for melanoma via inhibition of migration and invasion
Conditionally replicating adenoviruses (CRAds) represent a novel class of oncological therapeutic agents. One strategy to ensure tumour targeting is to place the essential viral genes under the control of tumo...
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Article
The deubiquitinating enzyme DUBAI stabilizes DIAP1 to suppress Drosophila apoptosis
Deubiquitinating enzymes (DUBs) counteract ubiquitin ligases to modulate the ubiquitination and stability of target signaling molecules. In Drosophila, the ubiquitin–proteasome system has a key role in the regula...
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Article
Astigmatism and biometric optic components of diode laser-treated threshold retinopathy of prematurity at 9 years of age
To assess the prevalence of astigmatism and its relationship with biometric optic components in preterm school children with diode laser-treated threshold retinopathy of prematurity (ROP).
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Article
Open AccessX-ray imaging of tumor growth in live mice by detecting gold-nanoparticle-loaded cells
We show that sufficient concentrations of gold nanoparticles produced by an original synthesis method in EMT-6 and CT-26 cancer cells make it possible to detect the presence, necrosis and proliferation of such...
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Article
Open AccessSecreted semaphorin 5A suppressed pancreatic tumour burden but increased metastasis and endothelial cell proliferation
Our earlier reports demonstrated that membrane-bound semaphorin 5A (SEMA5A) is expressed in aggressive pancreatic cancer cells and tumours, and promotes tumour growth and metastasis. In this study, we examine ...
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Article
Imaging the cellular uptake of tiopronin-modified gold nanoparticles
Well-dispersed gold nanoparticles (NP) coated with tiopronin were synthesized by X-ray irradiation without reducing agents. High-resolution transmission electron microscopy shows that the average core diameter...
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Article
In-Situ Characterization Of Ultra-Small Magnetic Junctions Made By Electrochemical Techniques
Electrochemical impedance spectroscopy is used to characterize the growth of NiO over Ni electrodes. We find a limited increase of thickness and a significant increase of porosity of the oxide as a function of...
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Article
Synchrotron microangiography studies of angiogenesis in mice with microemulsions and gold nanoparticles
We present an effective solution for the problem of contrast enhancement in phase-contrast microangiography, with the specific objective of visualising small (<8 µm) vessels in tumor-related microangiogenesis....
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Article
Long-term visual outcomes of laser-treated threshold retinopathy of prematurity: a study of refractive status at 7 years
To assess the long-term visual outcomes and refractive status in patients with diode laser-treated threshold retinopathy of prematurity (ROP), and to investigate the causes of impaired visual function.
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Article
Catalyst-free highly vertically aligned ZnO nanoneedle arrays grown by plasma-assisted molecular beam epitaxy
This work describes the growth of highly vertically aligned ZnO nanoneedle arrays on wafer-scale catalyst-free c-plane sapphire substrates by plasma-assisted molecular beam epitaxy under high Zn flux conditions. ...
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Article
Monitoring of land subsidence and ground fissures in **an, China 2005–2006: mapped by SAR interferometry
The City of **an, China, has been experiencing significant land subsidence and ground fissure activities since 1960s, which have brought various severe geohazards including damages to buildings, bridges and ot...
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Article
Cytotoxicity of silicone oil on cultivated human corneal endothelium
To investigate the cytotoxic effects of silicone oil on the cultivated human corneal endothelial cells (CEs).
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Article
Soft X-ray Magnetic Circular Dichroism and Photoemission Studies of II–VI Diluted Ferromagnetic Semiconductor Zn1−x Cr x Te
The electronic structure of the Cr ions in Zn1−x Cr x Te (x=0.03 and 0.15) has been investigated using X-ray magnetic circular dichroism (XMCD) and phot...
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Article
Metastatic choroidal abscess and choroidal neovascularization in a patient with Staphylococcus aureus renal abscess
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Article
Continuous-wave high-power (320 mW) single mode operation of electronic vertically coupled InAs/GaAs quantum dot narrow-ridge-waveguide lasers
High-power 3 μm-wide narrow-ridge-waveguide lasers with ten stacks of electronic vertically coupled InAs/GaAs quantum dots in the active region were demonstrated. Unlike that from conventional uncoupled InAs q...
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Article
Bacterial signal peptide recognizes HeLa cell mitochondrial import receptors and functions as a mitochondrial leader sequence
Phage display was used to identify new components of the mammalian mitochondrial receptor complex using Tom20 as a binding partner. Two peptides were identified. One had partial identity (SMLTVMA) with a bacte...
