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  1. Article

    Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated caspase-3-independent cell death

    p53 is a potent inhibitor of cell growth and an inducer of apoptosis. During embryonic development, Mdm2 and Mdm4 inhibit the growth suppressive activities of p53. However, whether tight surveillance of p53 ac...

    L S M Boesten, S M Zadelaar, S De Clercq, S Francoz… in Cell Death & Differentiation (2006)

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    Article

    Intra-CSF administered recombinant adenovirus causes an immune response-mediated toxicity

    High doses of adenotk were injected into the cerebrospinal fluid of rats and nonhuman primates (Macaca mulatta). Vector administration was followed by ganciclovir administration for 14 days. Despite the absenc...

    M J Driesse, M C Esandi, J M Kros, C J J Avezaat, ChJ Vecht, C Zurcher… in Gene Therapy (2000)

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    Article

    The Use of Intracerebral Microdialysis for the Determination of Pharmacokinetic Profiles of Anticancer Drugs in Tumor-Bearing Rat Brain

    Purpose. The use of intracerebral microdialysis as a tool to measure the penetration of anticancer agents in brain tumor was investigated.

    E. C. M. de Lange, J. D. de Vries, C. Zurcher, M. Danhof… in Pharmaceutical Research (1995)

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    Chapter

    Some Problems of Trial Design for Anti-Angiogenic Agents in Cancer Therapy

    The propensity of tumours to generate resistant clones is a major barrier to cytotoxic and hormone therapy. The vasculature of malignancies is a more appealing target, since tumour endothelial cells are not kn...

    Frank Arnold, H. Brem, G. Tamavokopulis, D. Tsakayannis, I. Gresser… in Angiogenesis (1994)

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    Chapter

    Tumour Induction in Animals and the Radiation Risk for Man

    It is now generally recognized that carcinogenesis is the most important detrimental effect in man after low dose irradiation. The carcinogenic action of ionizing radiation is clearly demonstrated after exposu...

    J. J. Broerse, J. Davelaar, C. Zurcher in Biological Effects and Physics of Solar an… (1993)

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    Article

    Flow cytometric DNA measurement and cytomorphometric analysis of formalin fixed rat mammary tumours

    Archival paraffin embedded material was used to examine whether additional quantitative criteria would be helpful to discriminate between histologically benign and malignant rat mammary tumours. To this end nu...

    MJJ Gijbels, JW Visser, HA Solleveld, JJ Broerse, C Zurcher in British Journal of Cancer (1991)

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    Article

    Radiation carcinogenesis in large animals

    C. Zurcher, M. J. van Zwieten, C. F. Hollander… in Radiation and Environmental Biophysics (1991)

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    Article

    Experimental immune mediated arthritis in rhesus monkeys

    The induction of experimental arthritis in rhesus monkeys was studied by intradermal immunization of bovine type II collagen and antigens derived fromMycobacterium tuberculosis, Streptococcus pyogenes, andEubacte...

    N. P. M. Bakker, M. G. van Erck, C. Zurcher, P. Faaber… in Rheumatology International (1990)

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    Article

    Radiation carcinogenesis in experimental animals

    Exposure of man to relatively high doses of ionizing radiation is generally restricted to accidental situations, with very limited knowledge about the actual doses received. Animal experiments can be performed...

    J. J. Broerse, D. W. van Bekkum, C. Zurcher in Experientia (1989)

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    Chapter and Conference Paper

    Cocultivation as a Tool for the Detection of Oncoviruses in Childhood Leukemia

    In our study on the possible role of type-C oncoviruses in human leukemia we applied the technique of cocultivation of human bone marrow cells with an animal indicator cell line. The cocultivation technique pr...

    K. Nooter, C. Zurcher, C. Coolen, P. Bentvelzen in Modern Trends in Human Leukemia III (1979)

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    Article

    C-type virus antigens detected by immuno-fluorescence in human bone tumour cultures

    IN several animal species, C-type oncogenic RNA viruses (oncornaviruses) cause malignant tumours of mesodermal origin, such as leukaemia, lymphomas and different kinds of sarcoma1. C-type oncornaviruses have rare...

    C. ZURCHER, J. BRINKHOF, P. BENTVELZEN, J. C. H. DE MAN in Nature (1975)

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    Article

    Der Faktore ug beiDrosophila Melanogaster: Lokalisation, Frequenzänderungen in Massenzuchten und Lebensleistungen Seiner Träger im Vergleich mit einem Wildstamm

    A factor causing dark pigmentation of the abdomen in females ofD. melanogaster has been located on the third chromosome, at locus69,8±0,4 morgans.

    C. Zürcher in Genetica (1964)