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Article
Open AccessHotline update of clinical trials and registries presented at the American College of Cardiology Congress 2010: ACCORD, INVEST, NAVIGATOR, RACE II, SORT OUT III, CSP-474, DOSE, ASPIRE and more
This article gives an overview on a number of novel clinical trials in the field of cardiovascular medicine, which were presented during the Late Breaking Clinical Trial Sessions at the 59th annual meeting of ...
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Article
Stentimplantation bei einem Koronararterienaneurysma Ein Fallbericht
The incidence of coronary artery aneurysm varies in the range from 0.2% to 4.9%. Ninety per cent of these were associated with atherosclerotic coronary artery disease, where vessel ectasia and poststenotic di...
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Article
Regulation of myocardial contractility and cardiac growth
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Chapter
Herzinsuffizienz
Die Herzinsuffizienz ist weiterhin eines der führenden klinischen Syndrome, deren ätiologisch zugrundeliegende Krankheiten vielfältig sind; die koronare Herzerkrankung muß nach großen Herzinsuffizienzstu-dien ...
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Chapter
Energieversorgung des gesunden Herzens
Das Herz als Pumpe benötigt für die Aufrechterhaltung der Blutzirkulation des Gesamtorganismus Energie, um die Druck-Volumen-Arbeit und die damit verbundene Förderleistung zu ermöglichen. Somit muß im Herzmusk...
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Article
Influence of endothelin 1 on human atrial myocardium—myocardial function and subcellular pathways
The influence of endothelin 1 on isometrically contracting human atrial muscle strip preparations was investigated under physiological conditions (37°C, 1 Hz, Ca2+ 2.5 mM). Endothelin dose-dependently increased i...
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Chapter and Conference Paper
Contractile protein function in failing and nonfailing human myocardium
Isometric heat and force measurements were used to relate mechanical performance to function of contractile proteins in muscle strips from failing and nonfailing human hearts (37°C, 60 beats per minute). Compa...
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Chapter and Conference Paper
Energetics of calcium cycling in nonfailing and failing human myocardium
Using sensitive antimony-bismuth thermopiles, isometric force and heat output were measured in muscle strips from nonfailing human hearts and from failing dilated cardio-myopathic hearts at a stimulation rate ...
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Article
Influence of isoproterenol on myocardial energetics. Experimental and clinical investigations
The influence of isoproterenol on myocardial performance and energetics was investigated in normal guinea pig myocardium and in patients with normal left ventricular function.
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Article
Influence of the calcium-sensitizer UDCG-115 on hemodynamics and myocardial energetics in patients with idiopathic dilated cardiomyopathy. Comparison with nitroprusside
UDCG-115 is a new cardiotonic agent which in vitro increases the sensitivity of the contractile proteins to calcium ions, inhibits the activity of phosphodiesterase, and prolongs the duration of the action pot...
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Chapter and Conference Paper
Influence of isoproterenol on myocardial energetics. Experimental and clinical investigations
The influence of isoproterenol on myocardial performance and energetics was investigated in normal guinea pig myocardium and in patients with normal left ventricular function.
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Chapter and Conference Paper
Influence of the calcium-sensitizer UDCG-115 on hemodynamics and myocardial energetics in patients with idiopathic dilated cardiomyopathy. Comparison with nitroprusside
UDCG-115 is a new cardiotonic agent which in vitro increases the sensitivity of the contractile proteins to calcium ions, inhibits the activity of phosphodiesterase, and prolongs the duration of the action pot...
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Chapter
Energieversorgung des gesunden Herzens
Das Herz als Pumpe benötigt für die Aufrechterhaltung der Blutzirkulation des Gesamtorganismus Energie, um die Druck-Volumen-Arbeit und somit die damit verbundene Förderleistung zu ermöglichen. Somit ist es un...
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Chapter
Herzinsuffizienz
Eine Herzinsuffizienz, d.h. die Unfähigkeit des Herzens, trotz ausreichenden venösen Blutangebotes ein unter Ruhe- und Belastungsbedingungen für den Bedarf des Organismus ausreichendes Herzminutenvolumen zu fö...
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Chapter and Conference Paper
Energetic Consequences of Pharmacological Therapy in Patients with Myocardial Failure
Reducing ventricular load and increasing the contractile force of the myocardium are fundamental principles in the pharmacological therapy of heart failure. Therapeutic goals are the relief of symptoms and the...
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Article
Estimation of left ventricular volume and mass by magnetic resonance imaging: Comparison with quantitative biplane angiocardiography
Magnetic resonance imaging (MRI) is well suited for the delineation of cardiac anatomy. In this study an estimation of left ventricular volume and muscle mass by MRI was attempted, using an iron-shielded resis...
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Chapter
Das Sportherz im Tierversuch: Einfluß eines chronischen Schwimmtrainings auf Herzdynamik, Myokardfunktion und kontraktile Proteine bei der Ratte
Results of training experiments with numerous groups of normotensive Wistar and Sprague-Dawley rats, as well as spontaneously hypertensive rats (SHR), are reported. Long-term swimming training (2–3 h/day for 5...
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Chapter
Adaptive and Pathological Alterations in Experimental Cardiac Hypertrophy
Based on investigations of various models of experimental cardiac hypertrophy (renal hypertension, spontaneous hypertension, aortic stenosis, swimming training, thyrotoxicosis), an attempt has been made to cha...
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Chapter
Prospects of X-ray microanalysis in the study of pathophysiology of myocardial contraction
X-ray microanalysis was used to compare chemically untreated cryosections of quick-frozen myocardial tissue in “caffeine contracture” with cryosections of normal muscle. Our goal was to find out if it is possi...
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Article
Prospects of X-ray microanalysis in the study of pathophysiology of myocardial contraction
X-ray microanalysis was used to compare chemically untreated cryosections of quick-frozen myocardial tissue in “caffeine contracture” with cryosections of normal muscle. Our goal was to find out if it is possi...
