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Article
Development of DNA delivery system using Pseudomonas exotoxin A and a DNA binding region of human DNA topoisomerase I
Gene therapy is defined as the delivery of a functional gene for expression in somatic tissues with the intent to cure a disease. Thus, highly efficient gene transfer is essential for gene therapy. Receptor-m...
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Article
Recombinant protein composed of Pseudomonas exotoxin A, outer membrane proteins I and F as vaccine against P. aeruginosa infection
We have constructed a chimeric protein composed of the receptor binding and membrane translocation domains of Pseudomonas exotoxin A (PE) with the outer membrane proteins I and F, together designated as PEIF. Th...
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Article
Genetic map** of DNA topoisomerase I-related sequences to mouse Chromosomes 2 and 14
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Chapter
RNA Structure in Solution and on the 30S Ribosomal Subunit
Evidence continues to mount that RNA plays many vital structural and functional roles of the ribosome in protein synthesis (for a review see Thompson and Hearst, 1983 a). Indeed, the recent discovery of cataly...
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Article
Map** the structure of macromolecular assemblies by combining chemical modification and separation methods
Several examples will be described in which powerful separation methods are combined with relatively simple chemical modification techniques to provide structural information on complex macromolecular assembli...
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Chapter and Conference Paper
RNA Structure, Free and on the Ribosome, as Revealed by Chemical and Enzymatic Studies
At present, various chemical and enzymatic probes are the experimental techniques capable of providing large amounts of data on the structure and arrangement of large RNA molecules. Direct reactivity measureme...