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Article
Minimally invasive longitudinal intravital imaging of cellular dynamics in intact long bone
Intravital two-photon microscopy enables deep-tissue imaging at high temporospatial resolution in live animals. However, the endosteal bone compartment and underlying bone marrow pose unique challenges to opti...
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Article
Open AccessSynergistic targeting of BRCA1 mutated breast cancers with PARP and CDK2 inhibition
Basal-like breast cancers (BLBC) are aggressive breast cancers that respond poorly to targeted therapies and chemotherapies. In order to define therapeutically targetable subsets of BLBC we examined two marker...
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Article
Author Correction: An atlas of genetic influences on osteoporosis in humans and mice
In the version of this article initially published, in Fig. 5a, the data in the right column of ‘DAAM2 gRNA1’ were incorrectly plotted as circles indicating ‘untreated’ rather than as squares indicating ‘treat...
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Article
An atlas of genetic influences on osteoporosis in humans and mice
Osteoporosis is a common aging-related disease diagnosed primarily using bone mineral density (BMD). We assessed genetic determinants of BMD as estimated by heel quantitative ultrasound in 426,824 individuals,...
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Article
Open AccessTargeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells
Although MYC is an attractive therapeutic target for breast cancer treatment, it has proven challenging to inhibit MYC directly, and clinically effective pharmaceutical agents targeting MYC are not yet availab...
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Article
Open AccessThe estrogen and c-Myc target gene HSPC111 is over-expressed in breast cancer and associated with poor patient outcome
Estrogens play a pivotal role in the initiation and progression of breast cancer. The genes that mediate these processes are not fully defined, but potentially include the known mammary oncogene MYC. Characteriza...
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Chapter
Identification of Downstream Targets of Estrogen and c-myc in Breast Cancer Cells
Estrogen (E) plays a pivotal regulatory role in the control of cell proliferation in the normal breast and breast cancer (BC). To identify genes with likely roles in proliferation control that are regulated by...
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Chapter and Conference Paper
Estrogens, Cell Proliferation and Breast Cancer
Control of cell proliferation in the normal mammary gland is steroid hormone (estrogen and progestin)-dependent and ultimately converges on activation of three proto-oncogenes (c-Myc, cyclin D1 and cyclin E1) ...
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Article
Regulation of cyclin expression and cell cycle progression in breast epithelial cells by the helix–loop–helix protein Id1
The helix–loop–helix protein Id1 has been implicated in regulating mammary epithelial cell proliferation and differentiation but the underlying molecular mechanisms are not well characterized. Under low serum ...
