25 Result(s)
within
Alexander Swarbrick
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Article
Open AccessPerformance of tumour microenvironment deconvolution methods in breast cancer using single-cell simulated bulk mixtures
Cells within the tumour microenvironment (TME) can impact tumour development and influence treatment response. Computational approaches have been developed to deconvolve the TME from bulk RNA-seq. Using scRNA-...
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Open AccessDNA barcoding reveals ongoing immunoediting of clonal cancer populations during metastatic progression and immunotherapy response
Cancers evade the immune system through the process of cancer immunoediting. While immune checkpoint inhibitors are effective for reactivating tumour immunity in some cancer types, many other solid cancers, in...
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Open AccessTemporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis
The tumour stroma, and in particular the extracellular matrix (ECM), is a salient feature of solid tumours that plays a crucial role in sha** their progression. Many desmoplastic tumours including breast can...
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Map** the cancer cell states conserved across solid tumors
A new study uses single-cell and spatial transcriptomics to provide a systematic characterization of the recurrent gene-expression programs that control neoplastic cell states in diverse cancers.
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Publisher Correction: Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells
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Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells
Skeletal muscle has long been recognized as an inhospitable site for disseminated tumour cells (DTCs). Yet its antimetastatic nature has eluded a thorough mechanistic examination. Here, we show that DTCs traff...
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A single-cell and spatially resolved atlas of human breast cancers
Breast cancers are complex cellular ecosystems where heterotypic interactions play central roles in disease progression and response to therapy. However, our knowledge of their cellular composition and organiz...
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Open AccessCryopreservation of human cancers conserves tumour heterogeneity for single-cell multi-omics analysis
High throughput single-cell RNA sequencing (scRNA-Seq) has emerged as a powerful tool for exploring cellular heterogeneity among complex human cancers. scRNA-Seq studies using fresh human surgical tissue are l...
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Open AccessProteogenomic analysis of Inhibitor of Differentiation 4 (ID4) in basal-like breast cancer
Basal-like breast cancer (BLBC) is a poorly characterised, heterogeneous disease. Patients are diagnosed with aggressive, high-grade tumours and often relapse with chemotherapy resistance. Detailed understandi...
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Open AccessHigh-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes
High-throughput single-cell RNA sequencing is a powerful technique but only generates short reads from one end of a cDNA template, limiting the reconstruction of highly diverse sequences such as antigen recept...
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Open AccessEpigenomics of mammary gland development
Differentiation of stem cells into highly specialised cells requires gene expression changes brought about by remodelling of the chromatin architecture. During this lineage-commitment process, the majority of ...
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Open AccessMASTL overexpression promotes chromosome instability and metastasis in breast cancer
MASTL kinase is essential for correct progression through mitosis, with loss of MASTL causing chromosome segregation errors, mitotic collapse and failure of cytokinesis. However, in cancer MASTL is most common...
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Open AccessTargeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer
The cellular and molecular basis of stromal cell recruitment, activation and crosstalk in carcinomas is poorly understood, limiting the development of targeted anti-stromal therapies. In mouse models of triple...
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Open AccessMicroRNAs as potential therapeutics to enhance chemosensitivity in advanced prostate cancer
Docetaxel and cabazitaxel are taxane chemotherapy treatments for metastatic castration-resistant prostate cancer (CRPC). However, therapeutic resistance remains a major issue. MicroRNAs are short non-coding RN...
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Open AccessPhase 2 study of circulating microRNA biomarkers in castration-resistant prostate cancer
Biomarkers of therapeutic response and prognosis are needed to assist in the sequencing of treatments for metastatic castration-resistant prostate cancer (CRPC). Previously in a Phase 1 discovery study, we ide...
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Open AccessMicroRNA profiling of the pubertal mouse mammary gland identifies miR-184 as a candidate breast tumour suppressor gene
The study of mammalian development has offered many insights into the molecular aetiology of cancer. We previously used analysis of mammary morphogenesis to discover a critical role for GATA-3 in mammary devel...
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ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype
Basal-like breast cancer (BLBC) is a heterogeneous disease with poor prognosis; however, its cellular origins and aetiology are poorly understood. In this study, we show that inhibitor of differentiation 4 (ID...
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Open AccessProfiling the tyrosine phosphoproteome of different mouse mammary tumour models reveals distinct, model-specific signalling networks and conserved oncogenic pathways
Although aberrant tyrosine kinase signalling characterises particular breast cancer subtypes, a global analysis of tyrosine phosphorylation in mouse models of breast cancer has not been undertaken to date. Thi...
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Open AccessNew insights into the role of ID proteins in breast cancer metastasis: a MET affair
The establishment of lethal metastases depends on the capacity of a small number of cancer cells to regenerate a tumor after entering a target organ. Stankic and colleagues have identified a role for the inhib...
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The Hedgehog signalling pathway in breast development, carcinogenesis and cancer therapy
Despite the progress achieved in breast cancer screening and therapeutic innovations, the basal-like subtype of breast cancer (BLBC) still represents a particular clinical challenge. In order to make an impact...
