4 Result(s)

Article

Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA)

In this study we aimed to evaluate the role of a SNP in intron 1 of the ERCC4 gene (rs744154), previously reported to be associated with a reduced risk of breast cancer in the general population, as a breast canc...

A Osorio, R L Milne, G Pita, P Peterlongo, T Heikkinen… in British Journal of Cancer (2009)

Article

The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers

The TP53 pathway, in which TP53 and its negative regulator MDM2 are the central elements, has an important role in carcinogenesis, particularly in BRCA1- and BRCA2-mediated carcinogenesis. A single nucleotide pol...

O M Sinilnikova, A C Antoniou, J Simard, S Healey, M Léoné… in British Journal of Cancer (2009)

Article

Single-nucleotide polymorphisms in the RB1 gene and association with breast cancer in the British population

A substantial proportion of the familial risk of breast cancer may be attributable to genetic variants each contributing a small effect. pRb controls the cell cycle and polymorphisms within it are candidates f...

F Lesueur, H Song, S Ahmed, C Luccarini, C Jordan, R Luben… in British Journal of Cancer (2006)

Article

The search for low-penetrance breast cancer genes

BAJ Ponder, A Cebrian, AM Dunning, DF Easton, F Lesueur… in Breast Cancer Research (2005)