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Article
Open AccessAssessment of innovative living and care arrangements for persons with dementia: a systematic review
Alternative forms of housing for persons with dementia have been developed in recent decades. These concepts offer small groups of residents familiar settings combined with efforts to provide normal daily life...
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Article
Double blinded, vehicle controlled, crossover study on the efficacy of a topical endocannabinoid membrane transporter inhibitor in atopic Beagles
The endocannabinoid system is important for skin homeostasis and alterations are linked to inflammatory diseases like atopic dermatitis (AD). Importantly, activation of cannabinoid receptor CB2 decreases pruri...
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Article
Determination of the antibacterial efficacy of a new porphyrin-based photosensitizer against MRSA ex vivo
Following extensive in vitro screening of new photosensitizers the purpose of the present study was to examine penetration as well as antibacterial efficacy of a lead photosensitizer against MRSA using an ex vivo
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Article
Structure-activity relationships of three differently substituted 2,7,12,17-tetrakis-(β-methoxyethyl) porphycene derivatives in vitro
The subcellular localization, efficacy and photooxidative mechanism of three new photosensitizing porphycenes (HexoTMPn, PeloTMPn, CpoTMPn) for photodynamic therapy with different substituents at position 9 of...
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Article
Open AccessEffects of light fractionation and different fluence rates on photodynamic therapy with 5-aminolaevulinic acid in vivo
To improve efficacy of photodynamic therapy (PDT) with intravenously administered 5-aminolaevulinic acid (ALA) fractionating the light dose or reducing the light intensity may be a possibility. Therefore, Syri...
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Chapter and Conference Paper
Can ICA Help Classify Skin Cancer and Benign Lesions?
Various neural network models for the identification and classification of different skin lesions from ALA-induced fluorescence images are presented. After different image preprocessing steps, eigenimages and ...
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Article
Open AccessOverexpression of melanoma inhibitory activity (MIA) enhances extravasation and metastasis of A-mel 3 melanoma cells in vivo
The secreted MIA protein is strongly expressed by advanced primary and metastatic melanomas but not in normal melanocytes. Previous studies have shown that MIA serum levels correlate with clinical tumour progr...
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Article
Leukocyte-Endothelium-Interaction in Pial Vessels Following Global, Cerebral Ischaemia
¶ Background. Investigations have shown an increase of leukocyte-endothelium-interaction in a variety of organs following an ischaemic insult. To elucidate the role of leukocyte-endothelium-interaction following ...
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Article
Open AccessPhoto-oxidative killing of human colonic cancer cells using indocyanine green and infrared light
Despite of the approval of Photofrin® in various countries, chemically defined sensitizers for photodynamic therapy (PDT) are still needed for the absorption of light in the infrared spectrum, which provides a...
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Article
Photodynamic Inactivation of Staphylococci with 5-Aminolaevulinic Acid or Photofrin
Widespread use of antibiotics for bacterial infections is a reason for antibiotic resistance. Therefore, alternatives like photodynamic therapy (PDT) are studied for bacterial eradication.
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Article
New Laser Literature
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Article
Indocyanine green and laser light for the treatment of AIDS-associated cutaneous Kaposi's sarcoma
Indocyanine green (ICG) is clinically approved for the determination of liver function, cardiac output and plasma volume. In this pilot study, ICG was used as photosensitizer in combination with a diode laser ...
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Article
Dosedependent photodynamic effects of 9-acetoxy-2,7,12,17-tetrakis(\-methoxyethyl)-porphycene in vitro
Porphycenes are chemically pure photosensitizers for topical and systemic photodynamic therapy (PDT). Fast cellular uptake of 9-acetoxy-2,7,12,17-tetrakis-(sB-methoxyethyl)porphycene (ATMPn) has been shown pre...
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Article
Influence of a haematoporphyrin derivative on the protoporphyrin IX synthesis and photodynamic effect after 5-aminolaevulinic acid sensitization in human colon carcinoma cells
Haematoporphyrin derivatives (HPDs) are potent sensitizers in photodynamic therapy (PDT), associated with prolonged skin photosensitivity. 5-Aminolaevulinic acid (5-ALA), a natural precusor of haem, is convert...
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Chapter and Conference Paper
Photodynamic Therapy of Skin Cancers: A New Therapeutic Alternative?
A photodynamic reaction is the excitation of a photosensitizer, mainly porphyrin derivatives, by visible light emitted by lamps or lasers in the presence of oxygen resulting in the generation of reactive oxyge...
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Article
Effects of photodynamic therapy on leucocyte-endothelium interaction: differences between normal and tumour tissue
An inflammatory reaction is regularly noticed in irradiated tissues following photodynamic therapy (PDT). This observation is potentially associated with leucocyte-mediated tissue damage, which might further c...
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Article
In vivo kinetics and spectra of 5-aminolaevulinic acid-induced fluorescence in an amelanotic melanoma of the hamster
For successful photodynamic diagnosis (PDD) and effective photodynamic therapy (PDT) with the clinically used 'photosensitiser' 5-aminolaevulinic acid (ALA), knowledge of the maximal fluorescence intensity and...
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Chapter and Conference Paper
Current Evidence on a Pathophysiological Function of Leukocyte/Endothelial Interactions in Cerebral Ischemia
Accumulation of leukocytes, particularly of polymorphonuclear neutrophils (PMNLs), is considered as an important response in tissue injury or infection. Recent investigations in a variety of organs, such as bo...
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Chapter and Conference Paper
Leukocyte/Endothelial Interactions and Blood-Brain Barrier Permeability in Rats During Cerebral Superfusion with LTB4
The experimental study analyses the vasomotor response (change of diameter of pial arterioles and venules), and blood-brain barrier function of the pia-arachnoidea at the rat brain surface before, during and a...
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Chapter and Conference Paper
White Blood Cell Behavior in the Cerebral Microcirculation
The role of white blood cells in acute cerebral disorders such as ischemia, stroke, or inflammation is not understood. Activated neutrophils might be involved, for example, in damage to the cerebrovascular end...
