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Article
Open AccessSelenophosphate synthetase 1 deficiency exacerbates osteoarthritis by dysregulating redox homeostasis
Aging and mechanical overload are prominent risk factors for osteoarthritis (OA), which lead to an imbalance in redox homeostasis. The resulting state of oxidative stress drives the pathological transition of ...
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Article
Open AccessProbiotic effect of Lactococcus lactis subsp. cremoris RPG-HL-0136 on intestinal mucosal immunity in mice
Lactococcus lactis subsp. cremoris is a lactic acid bacterium commonly used in the cheese manufacturing industry. It is known to produce antibacterial peptides and has recently received attention for its role as ...
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Article
Open AccessPhysalis alkekengi L. var. francheti alleviates neuronal cell death caused by activated microglia in vitro
Microglia are the macrophages that reside in the brain. Activated microglia induces further activation of astrocytes and neuronal cells for mounting an immune response. However, activated microglia release neu...
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Article
Open AccessEffect of sodium silicate on early growth stages of wheat under drought stress
Wheat yield is decreasing due to climate change, and a method to prevent decreasing yield during drought stress is desirable. In this study, wheat cultivars (Koso and Jokyung) were treated with 15% polyethylen...
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Article
Open AccessCharacterization of two leaf rust-resistant Aegilops tauschii accessions for the synthetic wheat development
Aegilops tauschii (Ae. tauschii) is a diploid (2n = 2x = 14) wild grass species, which has been reported as the progenitor of hexaploid wheat (Triticum aestivum) with D-genome. In this study, 68 Ae. tauschii acce...
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Article
Open AccessExpression of the methionine sulfoxide reductase lost during evolution extends Drosophila lifespan in a methionine-dependent manner
Accumulation of oxidized amino acids, including methionine, has been implicated in aging. The ability to reduce one of the products of methionine oxidation, free methionine-R-sulfoxide (Met-R-SO), is widespread i...
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Article
Open AccessSelenoprotein MsrB1 promotes anti-inflammatory cytokine gene expression in macrophages and controls immune response in vivo
Post-translational redox modification of methionine residues often triggers a change in protein function. Emerging evidence points to this reversible protein modification being an important regulatory mechanis...
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Chapter
Biochemistry and Function of Methionine Sulfoxide Reductase
Reactive oxygen species (ROS) oxidize methionine to a mixture of methionine-S-sulfoxide and methionine-R-sulfoxide. Methionine is also oxidized by various flavin-containing monooxygenases in a partially or fully ...
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Article
Monitoring methionine sulfoxide with stereospecific mechanism-based fluorescent sensors
The lack of existing tools has made it difficult to detect and quantify methionine sulfoxide in cells. The introduction of the MetSOx and MetROx fluorescent sensors allows detection of stereospecific forms of ...
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Article
Electromechanical method coupling non-invasive skin impedance probing and in vivo subcutaneous liquid microinjection: controlling the diffusion pattern of nanoparticles within living soft tissues
Transdermal drug delivery is the way to transport drug carriers, such as nanoparticles, across the skin barrier to the dermal and/or subcutaneous layer. In order to control the transdermal drug delivery proces...
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Article
Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status
Reduced methionine (Met) intake can extend lifespan of rodents; however, whether this regimen represents a general strategy for regulating aging has been controversial. Here we report that Met restriction exte...
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Chapter and Conference Paper
Budding Primo Microcells (Sanals) in a Culture Medium with Fertilized Egg Albumen and RPMI Medium
We developed a novel culture medium for primo microcells (PM) (sanals) by using a combination of fertilized egg albumen and RPMI-1640 medium (Gibco-Invitrogen, Carlsbad, CA, USA) (1:1). We observed the budding...
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Chapter and Conference Paper
Apoptotic Cardiomyocyte Beating Frequency Detected with Optical Intensity Fluctuation Spectrometer
Dynamical spectroscopy of intensity fluctuations allows measurements of the dynamic scattering of light and motility detection of biomicroparticles in suspensions and tissues. Spectroscopy of intensity fluctua...
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Chapter and Conference Paper
Development of the Putative Primo Vascular System Before the Formation of Vitelline Vessels in Chick Embryos
We found threadlike structures in the vitelline membrane and its surrounding dense albumen of a chick embryo by using the Trypan blue staining technique. The threadlike structure, a putative primo vessel, had ...
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Chapter and Conference Paper
Visualization of the Primo Vascular System by Using Trypan Blue in the Subarachnoid Space of Rats
One of the most recognized theories for the acupuncture meridian has been the concept that acupuncture effects propagate through the nervous system. Beyond this general concept in Western medicine, there was o...
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Chapter and Conference Paper
Identification of Primo Vascular System in Murine Tumors and Viscera
In the past decade, researchers at Seoul National University of South Korea have validated the existence of the primo-vascular system using animal models, which was originally reported by Bonghan Kim in the 19...
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Chapter and Conference Paper
Structure of the Sinus in the Primo Vessel Inside the Bovine Cardiac Chambers
We report the structure of sinuses in the primo vessels on the surfaces of endocardia of atriums and ventricles in the bovine heart. About 1–5 sinuses (0.5–7 μm in diameter) were observed in the cross sections...
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Chapter and Conference Paper
Effects of Cholinergic Drugs on Membrane Potential of Cells in Organ Surface Primo Nodes
The primo node (PN) was recently identified as a part of the primo network system in rats and rabbits. In this work, we studied the effects of acetylcholine, pilocarpine, and nifedipine, an antagonist of Ca2+ c...
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Chapter and Conference Paper
Network of the Primo Vascular System in the Rat Hypodermis
Anatomical and histological studies on acupuncture points (acupoints) and meridians have been one of the most important approaches to revealing the mechanism of acupuncture analgesia and therapeutics. However,...
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Article
Evidence for an Additional Metastatic Route: In Vivo Imaging of Cancer Cells in the Primo-Vascular System Around Tumors and Organs
Researchers have been studying the mechanisms by which metastasis can be prevented via blocking the hematogenous and the lymphatic routes for a long time now. However, metastasis is still the single most chall...
