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Article
Prenatal Care Utilization Challenges and Facilitators for a Growing Latino Community in the Midwest
Latina women are less likely to start prenatal care in the first trimester and to attend the recommended amount of prenatal visits compared to their non-Latina white counterparts.
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Article
Open AccessA novel Bayesian adaptive design incorporating both primary and secondary endpoints for randomized IIB chemoprevention study of women at increased risk for breast cancer
Our randomized controlled clinical trial will explore the potential of bazedoxifene plus conjugated estrogen to modulate breast tissue-based risk biomarkers as a surrogate for breast cancer risk reduction. Thi...
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Article
Open AccessOptimizing a Bayesian hierarchical adaptive platform trial design for stroke patients
Platform trials are well-known for their ability to investigate multiple arms on heterogeneous patient populations and their flexibility to add/drop treatment arms due to efficacy/lack of efficacy. Because of ...
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Article
Prenatal docosahexaenoic acid effect on maternal-infant DHA-equilibrium and fetal neurodevelopment: a randomized clinical trial
Maternal–infant equilibrium occurs when cord blood docosahexaenoic acid (DHA) is less than or equal to maternal DHA at delivery. Equilibrium may be an indicator of sufficient DHA for optimal fetal and infant n...
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Article
Open AccessUnifying the analysis of continuous and categorical measures of weight loss and incorporating group effect: a secondary re-analysis of a large cluster randomized clinical trial using Bayesian approach
Although frequentist paradigm has been the predominant approach to clinical studies for decades, some limitations associated with the frequentist null hypothesis significance testing have been recognized. Baye...
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Article
Open AccessComparison of hierarchical EMAX and NDLM models in dose-response for early phase clinical trials
Phase II clinical trials primarily aim to find the optimal dose and investigate the relationship between dose and efficacy relative to standard of care (control). Therefore, before moving forward to a phase II...
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Article
Open AccessUsing automated electronic medical record data extraction to model ALS survival and progression
To assess the feasibility of using automated capture of Electronic Medical Record (EMR) data to build predictive models for amyotrophic lateral sclerosis (ALS) outcomes.
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Article
Open AccessUsing an onset-anchored Bayesian hierarchical model to improve predictions for amyotrophic lateral sclerosis disease progression
Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig’s disease, is a rare disease with extreme between-subject variability, especially with respect to rate of disease progression. This makes modelling...
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Article
Open AccessChanging the default for tobacco-cessation treatment in an inpatient setting: study protocol of a randomized controlled trial
Most health care providers do not treat tobacco dependence routinely. This may in part be due to the treatment “default.” Current treatment guidelines recommend that providers (1) ask patients if they are will...
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Article
Open AccessAssessment of DHA on reducing early preterm birth: the ADORE randomized controlled trial protocol
Preterm birth contributes to 0.5 million deliveries in the United States (one of eight pregnancies) and poses a huge burden on public health with costs in the billions. Of particular concern is that the rate o...
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Article
Prenatal DHA supplementation and infant attention
Results of randomized trials on the effects of prenatal docosahexaenoic acid (DHA) on infant cognition are mixed, but most trials have used global standardized outcomes, which may not be sensitive to effects o...
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Article
Reducing Iron Deficiency in 18–36-months-old US Children: Is the Solution Less Calcium?
Objectives National surveys consistently identify iron deficiency (ID) in US children between 1 and 3 years of age, when the brain is rapidly develo** and vulnerable to the effects of I...
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Article
Open AccessA Bayesian comparative effectiveness trial in action: develo** a platform for multisite study adaptive randomization
In the last few decades, the number of trials using Bayesian methods has grown rapidly. Publications prior to 1990 included only three clinical trials that used Bayesian methods, but that number quickly jumped...
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Article
Open AccessBayesian accrual prediction for interim review of clinical studies: open source R package and smartphone application
Subject recruitment for medical research is challenging. Slow patient accrual leads to increased costs and delays in treatment advances. Researchers need reliable tools to manage and predict the accrual rate. ...
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Article
Open AccessA novel method for expediting the development of patient-reported outcome measures and an evaluation of its performance via simulation
Develo** valid and reliable patient-reported outcome measures (PROMs) is a critical step in promoting patient-centered health care, a national priority in the U.S. Small populations or rare diseases often po...
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Article
Sorting it out: pile sorting as a mixed methodology for exploring barriers to cancer screening
We discuss a mixed methodology for analyzing pile sorting data. We created a list of 14 barriers to colon cancer screening and recruited 18, 13, and 14 participants from three American Indian (AI) communities ...
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Article
Open AccessThe index of tobacco treatment quality: development of a tool to assess evidence-based treatment in a national sample of drug treatment facilities
Quitting smoking improves health and drug use outcomes among people in treatment for substance abuse. The twofold purpose of this study is to describe tobacco treatment provision across a representative sample...
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Article
Integrated analysis of content and construct validity of psychometric instruments
Establishing adequacy of psychometric properties of an instrument involves acquisition and evaluation of evidence based on item content and internal structure. Content validity evidence consists of subject mat...
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Article
Open AccessInput data quality control for NDNQI national comparative statistics and quarterly reports: a contrast of three robust scale estimators for multiple outlier detection
To evaluate institutional nursing care performance in the context of national comparative statistics (benchmarks), approximately one in every three major healthcare institutions (over 1,800 hospitals) across t...
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Article
Open AccessThe Box-Cox power transformation on nursing sensitive indicators: Does it matter if structural effects are omitted during the estimation of the transformation parameter?
Many nursing and health related research studies have continuous outcome measures that are inherently non-normal in distribution. The Box-Cox transformation provides a powerful tool for develo** a parsimonio...
