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Newborn susceptibility to infection vs. disease depends on complex in vivo interactions of host and pathogen

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  1. Article

    Open Access

    Angiogenesis-associated pathways play critical roles in neonatal sepsis outcomes

    Neonatal sepsis is a major cause of childhood mortality. Limited diagnostic tools and mechanistic insights have hampered our abilities to develop prophylactic or therapeutic interventions. Biomarkers in human ...

    Mario Fidanza, Julie Hibbert, Erica Acton, Danny Harbeson… in Scientific Reports (2024)

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  2. Article

    Open Access

    Human in vitro modeling of adjuvant formulations demonstrates enhancement of immune responses to SARS-CoV-2 antigen

    Adjuvants can enhance vaccine immunogenicity, but their mechanism of action is often incompletely understood, hampering rapid applicability for pandemic vaccines. Herein, we characterized the cellular and mole...

    Simon Doss-Gollin, Sanya Thomas, Byron Brook, Kimia Abedi, Célia Lebas… in npj Vaccines (2023)

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  3. Article

    Open Access

    Development of a TLR7/8 agonist adjuvant formulation to overcome early life hyporesponsiveness to DTaP vaccination

    Infection is the most common cause of mortality early in life, yet the broad potential of immunization is not fully realized in this vulnerable population. Most vaccines are administered during infancy and chi...

    David J. Dowling, Soumik Barman, Alyson J. Smith, Francesco Borriello… in Scientific Reports (2022)

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  4. Article

    Open Access

    mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant

    The SARS-CoV-2 Omicron variant evades vaccine-induced immunity. While a booster dose of ancestral mRNA vaccines effectively elicits neutralizing antibodies against variants, its efficacy against Omicron in old...

    Etsuro Nanishi, Marisa E. McGrath, Timothy R. O’Meara… in Communications Biology (2022)

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