8 Result(s)

Article

A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8

Small animal models have been a challenge for the study of SARS-CoV-2 transmission, with most investigators using golden hamsters or ferrets. Mice have the advantages of low cost, wide availability, less regul...

Bruno A. Rodriguez-Rodriguez, Grace O. Ciabattoni, Ralf Duerr… in Nature Communications (2023)

Article

Publisher Correction: Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice

Etsuro Nanishi, Francesco Borriello, Hyuk-Soo Seo, Timothy R. O’Meara… in npj Vaccines (2023)

Article

Immunogenicity and protection of a variant nanoparticle vaccine that confers broad neutralization against SARS-CoV-2 variants

SARS-CoV-2 variants have emerged with elevated transmission and a higher risk of infection for vaccinated individuals. We demonstrate that a recombinant prefusion-stabilized spike (rS) protein vaccine based on...

James Logue, Robert M. Johnson, Nita Patel, Bin Zhou… in Nature Communications (2023)

Article

Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice

Development of SARS-CoV-2 vaccines that protect vulnerable populations is a public health priority. Here, we took a systematic and iterative approach by testing several adjuvants and SARS-CoV-2 antigens to ide...

Etsuro Nanishi, Francesco Borriello, Hyuk-Soo Seo, Timothy R. O’Meara… in npj Vaccines (2023)

Article

PIKfyve-specific inhibitors restrict replication of multiple coronaviruses in vitro but not in a murine model of COVID-19

The ongoing COVID-19 pandemic has claimed more than 6 million lives and continues to test the world economy and healthcare systems. To combat this pandemic, the biological research community has shifted effort...

James Logue, Arup R. Chakraborty, Robert Johnson, Girija Goyal… in Communications Biology (2022)

Article

mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant

The SARS-CoV-2 Omicron variant evades vaccine-induced immunity. While a booster dose of ancestral mRNA vaccines effectively elicits neutralizing antibodies against variants, its efficacy against Omicron in old...

Etsuro Nanishi, Marisa E. McGrath, Timothy R. O’Meara… in Communications Biology (2022)

Article

Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

COVID-19 caused by the SARS-CoV-2 virus has become a global pandemic. 3CL protease is a virally encoded protein that is essential across a broad spectrum of coronaviruses with no close human analogs. PF-008352...

Britton Boras, Rhys M. Jones, Brandon J. Anson, Dan Arenson… in Nature Communications (2021)

Article

Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail

Understanding the molecular basis for immune recognition of SARS-CoV-2 spike glycoprotein antigenic sites will inform the development of improved therapeutics. We determined the structures of two human monoclo...

**hui Dong, Seth J. Zost, Allison J. Greaney, Tyler N. Starr… in Nature Microbiology (2021)