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Article
Highly Sensitive Fluorescence Detection of Daptomycin in Murine Samples through Derivatization with 2,3-Naphthalenedialdehyde
A highly sensitive high-performance liquid chromatography method has been developed using the pre-column fluorescent derivatization of daptomycin (DAP) through cyclization of the amino group of ornithine with ...
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Article
Preparation of N2-Ethyl-2′-deoxyguanosine-d4 as an Internal Standard for the Electrospray Ionization–Tandem Mass Spectrometric Determination of DNA Damage by Acetaldehyde
The deuteration of N2-ethyl-2′-deoxyguanosine (Et-dG), which is a DNA adduct generated from acetaldehyde, was studied by the addition reaction of acetaldehyde-d4 to 2′-deoxyguanosine (dG) in deuterium oxide (D2O)...
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Article
Preparation of Cyclic-1,N2-propano-2′-deoxyguanosine-d7 as an Internal Standard for ESI-MS/MS Determination of DNA Damage from Acetaldehyde
Cyclic-1,N2-propano-2′-deoxyguanosine-d7 (CPr-dG-d7) was prepared as an isotopic internal standard (IS) for electrospray ionization tandem mass spectrometry (ESI-MS/MS) quantification of CPr-dG in DNA as a candid...
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Article
Evaluation of Type-A Endonucleases for the Quantitative Analysis of DNA Damage due to Exposure to Acetaldehyde Using Capillary Electrophoresis
The substrate selectivities of three endonucleases were studied quantitatively using capillary zone electrophoresis to find one giving N2-ethyl(Et)-2′-deoxyguanosine-5′-monophosphate (5′-dGMP) and cyclic 1,N2-pro...
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Article
Sibel A. Ozkan, Jean-Michel Kauffmann, and Petr Zuman: Electroanalysis in biomedical and pharmaceutical sciences. Voltammetry, amperometry, biosensors, applications
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Article
Simple Pretreatment and HILIC Separation for LC-ESI-MS/MS Determination of Adenosine in Human Plasma
A simple pretreatment method and separation mode for the LC-ESI-MS/MS determination of adenosine in human plasma have been developed. Deproteinization by acetonitrile and ultrafiltration followed by chromatogr...
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Article
Facile and Effective Pretreatment Using Stop and Go Extraction Tips for LC-MS/MS Analysis of Trace Amounts of DNA Adducts
The preparation and application of a stop and go extraction tip (StageTip) used for pre-purification of sample solutions for LC-MS/MS analysis of DNA adducts was simplified and improved to increase throughput ...
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Article
Mechanistic Study on the Electrochemical Reduction of 9,10-Anthraquinone in the Presence of Hydrogen-bond and Proton Donating Additives
The electrochemical reduction of 9,10-anthraquinone (AQ) was investigated in CH3CN in both the absence and presence of the hydrogen-bond and proton donating additives, CH3OH, CH(CF3)2OH, phenol, 4-methoxyphenol, ...
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Article
Structural and Spectral Characteristics of the Cross-linked Dimer Derived from Electrooxidation of Cyclic 1,N2-Propanoguanosine
The acetaldehyde-derived cyclic propano adduct of 2′-deoxyguanosine was easily oxidized electrochemically into the cross-linked dimer as an oxidative product. The structural and spectroscopic characteristics o...
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Article
Functional Preconcentration Tip of Total Volume Injection for ESI/MS Analysis of DNA Adducts
We have developed a simple method to significantly improve the sensitivity in the LC/MS analysis of DNA adducts. A preconcentration tip for the selective recovery of DNA adducts was prepared. Using this tip, t...
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Article
Simultaneous Determination of Endocrine Disruptive Alkylphenolic Compounds as Dansyl Derivatives
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Article
Non-aqueous Capillary Electrophoresis of p-Quinone Anion Radicals
The electrophoretic detection of two kinds of p-quinone anion radicals arising from the electrolysis of benzoquinone and chloranil was achieved by employing an acetonitrile medium. Sufficient dehydration of a run...
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Chapter and Conference Paper
π-π Charge-Transfer Interaction of the Tetracyanoethylene π-Dianion Generated at Sequential Electroreduction Steps
Increased attention has been paid to the π-dianions of organic molecules generated at sequential electroreduction steps, as a noticeably active electron-donor. The π-π stacking interaction of the dianion plays...
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Article
High-Performance Liquid Chromatographic Determination of Urinary Malondialdehyde as p-Nitrophenylhydrazine Derivative
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Article
High-Performance Liquid Chromatographic Determination of Pyrroloquinoline Quinone as Acetone Adduct
A high performance liquid chromatographic method for the determination of pyrroloquinoline quinone (PQQ) is described. PQQ reacts readily with acetone in a weakly alkaline medium, giving a stable adduct, 5-ace...
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Article
In-Situ Electron Spin Resonance and Voltammetric Studies Using an Internal-Flow-Type Electrolysis Cell
A newly designed three-electrode electrolysis cell for in-situ electron spin resonance (ESR) spectroscopy and cyclic voltammetry is described. An electrolysis solution near the electrode surface is continuously r...
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Chapter
Electrochemical Study of the Mechanism and Kinetics of Oxygen Reduction Mediated by Anthracycline Antibiotics Adsorbed on Electrode Surface
It is well known that anthracycline antibiotics having an anthraquinone group in the molecule are an important class of widely used antitumor antibiotics1. Their clinical efficacy is limited by severe doserelated...
