The CRAC Channel
Methods and Protocols
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Open AccessCa2+ protein alpha 1D of CaV1.3 regulates intracellular calcium concentration and migration of colon cancer cells through a non-canonical activity
It is generally accepted that voltage-gated Ca2+ channels, CaV, regulate Ca2+ homeostasis in excitable cells following plasma membrane depolarization. Here, we show that the Ca2+ protein α1D of CaV1.3 channel is ...
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Constitutive calcium entry and cancer: updated views and insights
Tight control of basal cytosolic Ca2+ concentration is essential for cell survival and to fine-tune Ca2+-dependent cell functions. A way to control this basal cytosolic Ca2+ concentration is to regulate membrane ...
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Chapter
Role of Scaffolding Proteins in the Regulation of TRPC-Dependent Calcium Entry
Plasma membrane ion channels, and in particular TRPC channels need a specific membrane environment and association with scaffolding, signaling, and cytoskeleton proteins in order to play their important functi...
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Regulation by scaffolding proteins of canonical transient receptor potential channels in striated muscle
Recent studies proposed a pivotal role of TRPC channels, in particular TRPC1, in the striated muscle tissue and in the development of calcium mishandling observed in dystrophin-deficient skeletal and cardiac m...
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Open AccessPhenotypes induced by NM causing α-skeletal muscle actin mutants in fibroblasts, Sol 8 myoblasts and myotubes
Nemaline myopathy is a neuromuscular disorder characterized by the presence of nemaline bodies in patient muscles. 20% of the cases are associated with α-skeletal muscle actin mutations. We previously showed t...
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L-Glutamine Administration Reduces Oxidized Glutathione and MAP Kinase Signaling in Dystrophic Muscle of mdx Mice
To determine whether glutamine (Gln) reduces the ratio of oxidized to total glutathione (GSSG/GSH) and extracellular signal-regulated kinase (ERK1/2) activation in dystrophic muscle. Four-week old mdx mice, an an...
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New insights in the regulation of calcium transfers by muscle dystrophin-based cytoskeleton: implications in DMD
Calcium mishandling in Duchenne muscular dystrophy (DMD) suggested that dystrophin, a membrane-associated cytoskeleton protein, may regulate calcium-signalling cascades such as calcium entries. Calcium overloa...
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Differential interaction and activation of Rho family GTPases by p210bcr-abl and p190bcr-abl
The p210bcr-abl and p190bcr-abl fusion proteins, respectively responsible for chronic myelogenous leukemia and acute lymphoblastic leukemia, present deregulated tyrosine kinase activity and abnormal localization....
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Activation of a slow outward current by the calcium released during contraction of cultured rat skeletal muscle cells
A slow outward current, activated during depolarization, which induced contraction in whole-cell patch-clamped rat skeletal muscle cells in primary culture [10], was extensively characterized in the present st...
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Progressive predominance of ‘skeletal’ versus ‘cardiac’ types of excitation-contraction coupling during in vitro skeletal myogenesis
Simultaneous recordings, in the presence or absence of cadmium, of current and contraction of skeletal muscle cells in primary culture (myoballs) showed that the relative part of contraction depending on calci...
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Excitation-Contraction Coupling in Rat Skeletal Muscle Cells: Evolution During in Vitro Myogenesis
The fusion of mononucleated myoblasts into multinucleated myotubes is a crucial event during myogenesis since it precedes (without being a prerequisite) the appearance of a lot of molecules and processes vital...
