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    The Development and Mechanism Studies of Cationic Chitosan-Modified Biodegradable PLGA Nanoparticles for Efficient siRNA Drug Delivery

    In order to improve siRNA delivery for possible clinical applications, we developed biodegradable chitosan-modified poly(D,L-lactide-co-glycolide) (CHT-PLGA) nanoparticles with positive surface charge, high si...

    Xudong Yuan, Bruhal A. Shah, Naimesh K. Kotadia, Jian Li, Hua Gu… in Pharmaceutical Research (2010)