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  1. Article

    Open Access

    PAX6 suppression of glioma angiogenesis and the expression of vascular endothelial growth factor A

    We reported that PAX6 suppresses glioblastoma cell growth in vivo and anchorage-independent growth without significant alteration of cell proliferation in vitro, suggesting that PAX6 may alter the tumor microe...

    Yi-Hong Zhou, Yuanjie Hu, Debra Mayes, Eric Siegel, Jae G. Kim… in Journal of Neuro-Oncology (2010)

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    Article

    Enhanced cytotoxic effects of 5-aminolevulinic acid-mediated photodynamic therapy by concurrent hyperthermia in glioma spheroids

    During photodynamic therapy (PDT) both normal and pathological brain tissue, in close proximity to the light source, can experience significant temperature increases. The purpose of this study was to investiga...

    Henry Hirschberg, Chung-Ho Sun, Bruce J. Tromberg… in Journal of Neuro-Oncology (2004)

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    Article

    Repetitive 5-aminolevulinic acid-mediated photodynamic therapy on human glioma spheroids

    The response of human glioma spheroids to repetitive 5-aminolevulinic acid-mediated photodynamic therapy (PDT) was investigated. In all cases, light fluences were kept below toxic thresholds to simulate condit...

    Steen J. Madsen, Chung-Ho Sun, Bruce J. Tromberg… in Journal of Neuro-Oncology (2003)

  4. No Access

    Article

    ALA- and ALA-ester-mediated Photodynamic Therapy of Human Glioma Spheroids

    The effects of photodynamic therapy (PDT) in human glioma spheroids incubated in 5-aminolevulinic acid (ALA), or ALA esters, are investigated. Spheroid survival and growth are monitored following PDT at repres...

    Henry Hirschberg, Chung-Ho Sun, Bruce J. Tromberg… in Journal of Neuro-Oncology (2002)