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Article
Open AccessParkin coregulates glutathione metabolism in adult mammalian brain
We recently discovered that the expression of PRKN, a young-onset Parkinson disease-linked gene, confers redox homeostasis. To further examine the protective effects of parkin in an oxidative stress model, we fir...
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Article
Open AccessAge-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites
The mechanisms by which parkin protects the adult human brain from Parkinson disease remain incompletely understood. We hypothesized that parkin cysteines participate in redox reactions and that these are refl...
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Article
Culling of APCs by inflammatory cell death pathways restricts TIM3 and PD-1 expression and promotes the survival of primed CD8 T cells
We evaluated the impact of premature cell death of antigen-presenting cells (APCs) by Caspase-1- and RipK3-signaling pathways on CD8+ T-cell priming during infection of mice with Salmonella typhimurium (ST). Our ...
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Article
Open AccessHolocranohistochemistry enables the visualization of α-synuclein expression in the murine olfactory system and discovery of its systemic anti-microbial effects
Braak and Del Tredici have proposed that typical Parkinson disease (PD) has its origins in the olfactory bulb and gastrointestinal tract. However, the role of the olfactory system has insufficiently been explo...
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Chapter
The Detrimental Role of Type I Interferon Signaling During Infection with Salmonella typhimurium
Pathogenic Salmonella species reside in the phagosomes of infected cells and inject various virulence factors into the phagosome and cytoplasm of the host cell to evade the defense mechanisms. During infection of...
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Article
CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing
Alternative splicing of pre-messenger RNA is a key feature of transcriptome expansion in eukaryotic cells, yet its regulation is poorly understood. Spliceosome assembly occurs co-transcriptionally, raising the...
