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Article
Email bombing attack detection and mitigation using machine learning
Email bombing, a growingly prevalent and destructive cyber attack, involves inundating a target’s email inbox with subscription confirmation messages from legitimate services. This type of attack, particularly...
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Article
ROS production by mitochondria: function or dysfunction?
In eukaryotic cells, ATP generation is generally viewed as the primary function of mitochondria under normoxic conditions. Reactive oxygen species (ROS), in contrast, are regarded as the by-products of respira...
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Article
Potential role for protein kinase D inhibitors in prostate cancer
Protein kinase D (PrKD), a novel serine-threonine kinase, belongs to a family of calcium calmodulin kinases that consists of three isoforms: PrKD1, PrKD2, and PrKD3. The PrKD isoforms play a major role in path...
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Chapter and Conference Paper
Forensic Analysis and Detection of Spoofing Based Email Attack Using Memory Forensics and Machine Learning
Emails encounter many types of cyber-attacks and email spoofing is one of the most common and challenging investigation problems. This paper identifies spoofing-based email attacks in an organization by analyz...
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Article
3JC48-3 (methyl 4′-methyl-5-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)-[1,1′-biphenyl]-3-carboxylate): a novel MYC/MAX dimerization inhibitor reduces prostate cancer growth
The proto-oncogene cellular myelocytomatosis (c-Myc) is a transcription factor that is upregulated in several human cancers. Therapeutic targeting of c-Myc remains a challenge because of a disordered protein t...
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Article
Open AccessTraceless cysteine-linchpin enables precision engineering of lysine in native proteins
The maintenance of machinery requires its operational understanding and a toolbox for repair. The methods for the precision engineering of native proteins meet a similar requirement in biosystems. Its success ...
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Article
Identification and Counting of Hosts Behind NAT Using Machine Learning
NAT is a process of deploying a large number of hosts (typically in a LAN) to use a single or group of limited public IP address. The anonymity that NAT provides is a privilege for legitimate user, but it is a...
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Chapter
Epigenetic Regulation During Hypoxia and Its Implications in Cancer
Hypoxia is defined as a cellular stress condition caused by a decrease in oxygen below physiologically normal levels. Cells in the core of a rapidly growing solid tumor are faced with the challenge of inadequa...
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Article
Open AccessE2F1 and epigenetic modifiers orchestrate breast cancer progression by regulating oxygen-dependent ESRP1 expression
Epithelial splicing regulatory protein 1 (ESRP1) is an RNA binding protein that governs the alternative splicing events related to epithelial phenotypes. ESRP1 contributes significantly at different stages of ...
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Article
Open AccessTumor suppressor SMAR1 regulates PKM alternative splicing by HDAC6-mediated deacetylation of PTBP1
Highly proliferating cancer cells exhibit the Warburg effect by regulation of PKM alternative splicing and promoting the expression of PKM2. Majority of the alternative splicing events are known to occur in the n...
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Article
Hypoxia-induced alternative splicing in human diseases: the pledge, the turn, and the prestige
Maintenance of oxygen homeostasis is an indispensable criterion for the existence of multicellular life-forms. Disruption of this homeostasis due to inadequate oxygenation of the respiring tissues leads to pat...
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Article
Hypoxia-induced changes in intragenic DNA methylation correlate with alternative splicing in breast cancer
The tumor microenvironment is marked by gradients in the level of oxygen and nutrients, with oxygen levels reaching a minimum at the core of the tumor, a condition known as tumor hypoxia. Mediated by members o...
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Article
Open AccessDietary-phytochemical mediated reversion of cancer-specific splicing inhibits Warburg effect in head and neck cancer
The deregulated alternative splicing of key glycolytic enzyme, Pyruvate Kinase muscle isoenzyme (PKM) is implicated in metabolic adaptation of cancer cells. The splicing switch from normal PKM1 to cancer-speci...
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Article
Open AccessPAK2–c-Myc–PKM2 axis plays an essential role in head and neck oncogenesis via regulating Warburg effect
The histone modifiers (HMs) are crucial for chromatin dynamics and gene expression; however, their dysregulated expression has been observed in various abnormalities including cancer. In this study, we have an...
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Article
Apigenin induces apoptosis by targeting inhibitor of apoptosis proteins and Ku70–Bax interaction in prostate cancer
Dysfunction of the apoptotic pathway in prostate cancer cells confers apoptosis resistance towards various therapies. A novel strategy to overcome resistance is to directly target the apoptotic pathway in canc...
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Article
Apigenin Attenuates Insulin-Like Growth Factor-I Signaling in an Autochthonous Mouse Prostate Cancer Model
Deregulation of IGF signaling plays an important role in prostate cancer and contributes to invasion and metastasis. We determined the effect of apigenin, a plant flavone, on IGF signaling and its downstream t...
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Chapter
Current Status and Future Prospects of Nutraceuticals in Prostate Cancer
Nutraceuticals are products derived from food sources that provide health benefits. Several natural dietary agents have been studied for their preventive and/or therapeutic effects against prostate cancer. Alt...
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Article
CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing
Alternative splicing of pre-messenger RNA is a key feature of transcriptome expansion in eukaryotic cells, yet its regulation is poorly understood. Spliceosome assembly occurs co-transcriptionally, raising the...
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Article
Apigenin: A Promising Molecule for Cancer Prevention
Apigenin, a naturally occurring plant flavone, abundantly present in common fruits and vegetables, is recognized as a bioactive flavonoid shown to possess anti-inflammatory, antioxidant and anticancer properti...
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Article
Effect of herbal hypoglycemic agents on oxidative stress and antioxidant status in diabetic rats
In the present study the antioxidative potential ofMomordica charantia, Azadirachta indica, Allium sativum andOcimum sanctum was assessed in streptozotocin induced diabetic rats. Lipid peroxide levels were also m...
