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Article
E3 ubiquitin ligase TRIM31 alleviates dopaminergic neurodegeneration by promoting proteasomal degradation of VDAC1 in Parkinson’s Disease model
Mitochondrial dysfunction plays a pivotal role in the pathogenesis of Parkinson’s disease (PD). As a mitochondrial governor, voltage-dependent anion channel 1 (VDAC1) is critical for cell survival and death si...
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Article
Open AccessOTUD5 promotes the inflammatory immune response by enhancing MyD88 oligomerization and Myddosome formation
Myddosome is an oligomeric complex required for the transmission of inflammatory signals from TLR/IL1Rs and consists of MyD88 and IRAK family kinases. However, the molecular basis for the self-assemble of Mydd...
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Article
Open AccessSolvent-free selective hydrogenation of nitroaromatics to azoxy compounds over Co single atoms decorated on Nb2O5 nanomeshes
The solvent-free selective hydrogenation of nitroaromatics to azoxy compounds is highly important, yet challenging. Herein, we report an efficient strategy to construct individually dispersed Co atoms decorate...
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Article
Open AccessAuthor Correction: The protein arginine methyltransferase PRMT9 attenuates MAVS activation through arginine methylation
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Article
Contact Electrification Spectrum for Performance Enhancement Mechanism Investigation of Triboelectric Nanogenerators based on Silicone Elastomers with Different Surface Microstructures
Triboelectric nanogenerators (TENGs) based on conjunctive effects of contact electrification (CE) and electrostatic induction are emerging as a new mechanical energy harvesting and sensing technique for promis...
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Article
MAVS-loaded unanchored Lys63-linked polyubiquitin chains activate the RIG-I-MAVS signaling cascade
The adaptor molecule MAVS forms prion-like aggregates to govern the RIG-I-like receptor (RLR) signaling cascade. Lys63 (K63)-linked polyubiquitination is critical for MAVS aggregation, yet the underlying mecha...
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Article
Open AccessIdentification and experimental validation of autophagy-related genes in abdominal aortic aneurysm
Autophagy plays essential roles in abdominal aortic aneurysm (AAA) development and progression. The objective of this study was to verify the autophagy-related genes (ARGs) underlying AAA empirically and using...
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Article
CD-NTase family member MB21D2 promotes cGAS-mediated antiviral and antitumor immunity
cGAS/DncV-like nucleotidyltransferase (CD-NTase) family members are immune sensors that synthesize diverse nucleotide signals to initiate antiviral response in bacteria and animals. As a founding member of CD-...
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Article
USP3 deubiquitinates and stabilizes the adapter protein ASC to regulate inflammasome activation
Inflammasomes are essential components of the innate immune system and its defense against infections, whereas the dysregulation of inflammasome activation has a detrimental effect on human health. The activat...
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Article
Open AccessThe protein arginine methyltransferase PRMT9 attenuates MAVS activation through arginine methylation
The signaling adaptor MAVS forms prion-like aggregates to activate the innate antiviral immune response after viral infection. However, spontaneous aggregation of MAVS can lead to autoimmune diseases. The mole...
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Article
The E3 ubiquitin ligase TRIM31 plays a critical role in hypertensive nephropathy by promoting proteasomal degradation of MAP3K7 in the TGF-β1 signaling pathway
Renal fibrosis and inflammation are critical for the initiation and progression of hypertensive renal disease (HRD). However, the signaling mechanisms underlying their induction are poorly understood, and the ...
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Article
Open AccessPrivacy preserving divisible double auction with a hybridized TEE-blockchain system
Double auction mechanisms have been designed to trade a variety of divisible resources (e.g., electricity, mobile data, and cloud resources) among distributed agents. In such divisible double auction, all the ...
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Article
TRIM26 positively regulates the inflammatory immune response through K11-linked ubiquitination of TAB1
Protein ubiquitination plays an important role in the regulation of TGF-β-activated kinase 1 (TAK1)-mediated NF-κB activation. It is well established that TAK1 activation is tightly regulated with its binding ...
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Article
Open AccessThe overexpression of Tipe2 in CRC cells suppresses survival while endogenous Tipe2 accelerates AOM/DSS induced-tumor initiation
Aging is a natural and progressive process characterized by an increased frequency of age-related diseases such as cancer. But its mechanism is unclear. TNFAIP8L2 (Tipe2) is an important negative regulator for...
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Article
Open AccessTRIM31 facilitates K27-linked polyubiquitination of SYK to regulate antifungal immunity
Spleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase, which plays an essential role in both innate and adaptive immunity. However, the key molecular mechanisms that regulate SYK activity are poorly u...
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Article
OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING
Stimulator of interferon genes (STING) is an adaptor protein that is critical for effective innate antiviral and antitumor immunity. The activity of STING is heavily regulated by protein ubiquitination, which ...
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Article
Open AccessUSP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS
Activation of MAVS, an adaptor molecule in Rig-I-like receptor (RLR) signaling, is indispensable for antiviral immunity, yet the molecular mechanisms modulating MAVS activation are not completely understood. U...
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Chapter and Conference Paper
Efficient and Private Divisible Double Auction in Trusted Execution Environment
Auction mechanisms for exchanging divisible resources (e.g., electricity, cloud resources, and network bandwidth) among distributed agents have been extensively studied. In particular, divisible double auction...
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Article
MOF-Derived Cu-Nanoparticle Embedded in Porous Carbon for the Efficient Hydrogenation of Nitroaromatic Compounds
Novel Cu-nanoparticles (NPs) embedded in porous carbon materials (Cu@C-x) were prepared by one-pot pyrolysis of metal–organic frameworks (MOF) HKUST-1 at different temperatures. The obtained material Cu@C-x wa...
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Article
The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination
Sensors of RNA viruses trigger prion-like aggregation of the adaptor MAVS, which leads to antiviral responses. Gao and colleagues show that the E3 ligase TRIM31 positively regulates this process by K63-linked ...
