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Article
Open AccessResponse of treatment-naive brain metastases to stereotactic radiosurgery
With improvements in survival for patients with metastatic cancer, long-term local control of brain metastases has become an increasingly important clinical priority. While consensus guidelines recommend surge...
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Article
Open AccessThe genomic alterations in glioblastoma influence the levels of CSF metabolites
Cerebrospinal fluid (CSF) analysis is underutilized in patients with glioblastoma (GBM), partly due to a lack of studies demonstrating the clinical utility of CSF biomarkers. While some studies show the utilit...
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Article
Rapid detection of mutations in CSF-cfTNA with the Genexus Integrated Sequencer
Genomic alterations are fundamental for molecular-guided therapy in patients with breast and lung cancer. However, the turn-around time of standard next-generation sequencing assays is a limiting factor in the...
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Article
Myeloid-specific KDM6B inhibition sensitizes glioblastoma to PD1 blockade
Glioblastoma (GBM) tumors are enriched in immune-suppressive myeloid cells and are refractory to immune checkpoint therapy (ICT). Targeting epigenetic pathways to reprogram the functional phenotype of immune-s...
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Article
Open AccessOncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial
Immune-mediated anti-tumoral responses, elicited by oncolytic viruses and augmented with checkpoint inhibition, may be an effective treatment approach for glioblastoma. Here in this multicenter phase 1/2 study...
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Article
Open AccessSingle-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target
A major rate-limiting step in develo** more effective immunotherapies for GBM is our inadequate understanding of the cellular complexity and the molecular heterogeneity of immune infiltrates in gliomas. Here...
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Article
Long term outcomes following surgery for pineal region tumors
Pineal region tumors are surgically demanding tumors to resect. Long term neuro-oncologic outcomes following surgical excision of tumors from this region have been underreported. We sought to define the long t...
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Open AccessAuthor Correction: Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling
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Article
Considerations for designing preclinical cancer immune nanomedicine studies
Immunotherapy is known to be clinically beneficial for cancer patients and in many cases represents the new standard of care. Because of this success, the interest in integrating nanomedicine with cancer immun...
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Article
Megalencephalic leukoencephalopathy with subcortical cysts 1 (MLC1) promotes glioblastoma cell invasion in the brain microenvironment
Glioblastoma (GBM), or grade IV astrocytoma, is a malignant brain cancer that contains subpopulations of proliferative and invasive cells that coordinately drive primary tumor growth, progression, and recurren...
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Article
Open AccessThe role of resting-state functional MRI for clinical preoperative language map**
Task-based functional MRI (tb-fMRI) is a well-established technique used to identify eloquent cortex, but has limitations, particularly in cognitively impaired patients who cannot perform language paradigms. R...
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Article
Open AccessA cancer drug atlas enables synergistic targeting of independent drug vulnerabilities
Personalized cancer treatments using combinations of drugs with a synergistic effect is attractive but proves to be highly challenging. Here we present an approach to uncover the efficacy of drug combinations ...
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Article
Open AccessMetastatic Brain Tumors Disrupt the Blood-Brain Barrier and Alter Lipid Metabolism by Inhibiting Expression of the Endothelial Cell Fatty Acid Transporter Mfsd2a
Disruption of the blood-brain barrier (BBB) by cancer cells is linked to metastatic tumor initiation and progression; however, the pathways that drive these events remain poorly understood. Here, we have devel...
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Article
Open AccessAtrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling
Mutational inactivation of the SWI/SNF chromatin regulator ATRX occurs frequently in gliomas, the most common primary brain tumors. Whether and how ATRX deficiency promotes oncogenesis by epigenomic dysregulation...
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Article
Open AccessSuppression of RAF/MEK or PI3K synergizes cytotoxicity of receptor tyrosine kinase inhibitors in glioma tumor-initiating cells
The majority of glioblastomas have aberrant receptor tyrosine kinase (RTK)/RAS/phosphoinositide 3 kinase (PI3K) signaling pathways and malignant glioma cells are thought to be addicted to these signaling pathw...
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Article
Genetic, epigenetic, and molecular landscapes of multifocal and multicentric glioblastoma
Ten to twenty percent of newly diagnosed glioblastoma (GBM) patients initially present with multiple lesions, termed multifocal or multicentric GBM (M-GBM). The prognosis of these patients is poorer than that ...
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Article
A history of the AANS/CNS Section on Tumors Biennial Satellite Symposium
The Biennial Satellite Tumor Symposium is the flagship meeting of the AANS/CNS Section on Tumors. The year 2013 marked the 10th Tumor Section Biennial Satellite Tumor Symposium, a significant milestone warrant...
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Article
Existence of glioma stroma mesenchymal stemlike cells in Korean glioma specimens
It was presented that mesenchymal stem cells (MSCs) can be isolated from western glioma specimens. However, whether MSCs exist in glioma specimens of different ethnicities is unknown. To verify the existence o...
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Article
Isolation of glioma cancer stem cells in relation to histological grades in glioma specimens
The existence of cancer stem cells (CSCs) in glioblastoma has been proposed. However, the unknown knowledge that is yet to be revealed is the presence of glioma CSCs (gCSCs) in correlation to each WHO grades o...
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Changes in the biological characteristics of glioma cancer stem cells after serial in vivo subtransplantation
Currently, the interaction between the niche and glioma cancer stem cells (gCSCs) is gaining attention. However, there are few studies concerned with the effects of repeated exposure to a new microenvironment ...
