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Article
Open AccessSpaceflight and hind limb unloading induces an arthritic phenotype in knee articular cartilage and menisci of rodents
Reduced knee weight-bearing from prescription or sedentary lifestyles are associated with cartilage degradation; effects on the meniscus are unclear. Rodents exposed to spaceflight or hind limb unloading (HLU)...
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Article
Open AccessCD117/c-kit defines a prostate CSC-like subpopulation driving progression and TKI resistance
Cancer stem-like cells (CSCs) are associated with cancer progression, metastasis, and recurrence, and may also represent a subset of circulating tumor cells (CTCs). In our prior study, CTCs in advanced prostat...
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Reference Work Entry In depth
Integrin Alpha V (ITGAV)
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Article
Open AccessStability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium
The signalling pathways operational in quiescent, post-development vasculature remain enigmatic. Here we show that unlike neovascularization, endothelial Akt signalling in established vasculature is crucial no...
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Article
The dark side of the oxidative force in angiogenesis
A new mechanism regulating pathological angiogenesis has been identified that involves the activation of ataxia-telangiectasia mutated (Atm) kinase in response to reactive oxygen species. Importantly, this Atm...
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Article
Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands
Inflammation is known to cause oxidative stress and the growth of new blood vessels, and now a molecular mechanism linking these processes has been found. Oxidized products of lipid oxidation — (carboxy alkyl)...
