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Article
Open AccessEfficacy and quality of life for FOLFOX/bevacizumab +/− irinotecan in first-line metastatic colorectal cancer—final results of the AIO CHARTA trial
FOLFOXIRI plus bevacizumab has demonstrated benefits for metastatic colorectal cancer (mCRC) patients. However, challenges arise in its clinical implementation due to expected side effects and a lack of strati...
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Living Reference Work Entry In depth
Regionale Chemotherapie bei extrahepatischen Tumoren/Metastasen
Während die leberarterielle Chemotherapie einen gewissen Stellenwert in der Behandlung von Lebermetastasen kolorektaler Karzinome besitzt, sind die Daten zur regionalen Chemotherapie von extrahepatischen Tumor...
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Living Reference Work Entry In depth
Regionale Chemotherapie/Chemoembolisation von Lebermetastasen
Regionale Therapieverfahren werden zur gezielten Behandlung eines tumor- oder metastasentragenden Organs oder Organsystems eingesetzt. Sie werden einerseits von den lokalen (z. B. chirurgischen oder ablativen)...
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Living Reference Work Entry In depth
Lokoregionäre Radionuklidtherapie
Die lokoregionäre Radionuklidtherapie ist eine Form der Brachytherapie (griech. brachys: kurz, nah), bei der ein radioaktiver Strahler auf venösem Weg für die Radiopeptidtherapie (RPT) bzw. Peptid-Rezeptor-Rad...
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Article
Open AccessUpfront FOLFOXIRI+bevacizumab followed by fluoropyrimidin and bevacizumab maintenance in patients with molecularly unselected metastatic colorectal cancer
The addition of bevacizumab (BEV) to standard doublet chemotherapy improves outcomes compared with chemotherapy alone in patients with metastatic colorectal cancer (mCRC). The OPAL study examined the effect of...
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Article
Open AccessInterventionally implanted port catheter systems for hepatic arterial infusion of chemotherapy in patients with primary liver cancer: A phase II-study (NCT00356161)
Hepatic arterial infusion (HAI) of chemotherapy requires the implantation of a transcatheter application system which is traditionally performed by surgery. This procedure, but particularly the adjacent drug a...
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Article
Matched-Pair Comparison of Radioembolization Plus Best Supportive Care Versus Best Supportive Care Alone for Chemotherapy Refractory Liver-Dominant Colorectal Metastases
This study was designed to evaluate overall survival after radioembolization or best supportive care (BSC) in patients with chemotherapy-refractory liver-dominant metastatic colorectal cancer (mCRC).
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Article
Open AccessTreatment with bevacizumab and FOLFOXIRI in patients with advanced colorectal cancer: presentation of two novel trials (CHARTA and PERIMAX) and review of the literature
More than half of patients with colorectal cancer will develop metastatic disease either evident at the time of initial diagnosis or during their course of disease. Besides multidisciplinary management further...
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Chapter
Induced Hyperthermia in the Treatment of Cancer
The term “hyperthermia” summarizes the treatment of malignant diseases by application of heat by using different techniques. Hyperthermia is usually applied as an adjunct to an established treatment modality c...
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Article
Thrombocytopenia as first manifestation of splenic angiosarcoma
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Article
Adult jejunojejunal intussusception caused by metastasized pleomorphic carcinoma of the lung: Report of a case
Adult small-intestinal intussusception is rare and very different from childhood intussusception. Both benign and malignant pathologies can underlie small intestinal intussusception in adults, but malignancy i...
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Article
Phase II Feasibility Study on the Combination of Two Different Regional Treatment Approaches in Patients with Colorectal “Liver-Only” Metastases: Hepatic Interstitial Brachytherapy Plus Regional Chemotherapy
The aim of this study was to evaluate the feasibility, safety, and efficacy of combined treatment with hepatic interstitial brachytherapy (HIB) and hepatic arterial infusion (HAI) of chemotherapy after interve...
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Chapter
Perfusion Scintigraphy with Integrated Single Photon Emission Computed Tomography/Computed Tomography in the Management of Transarterial Treatment of Hepatic Malignancies
During the recent years it has been shown that transarterial applications of anticancer agents are promising approaches in the treatment of hepatic malignancies. While new techniques led to a reappraisal of he...
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Article
Planning transarterial radioembolization of colorectal liver metastases with Yttrium 90 microspheres: evaluation of a sequential diagnostic approach using radiologic and nuclear medicine imaging techniques
The purpose of the study was to establish a diagnostic approach to the preparation of patients with colorectal liver metastases considered for transarterial radioembolization (RE). Twenty-two patients sequenti...
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Article
Open AccessInterventionally implanted port catheter systems for hepatic arterial infusion of chemotherapy in patients with colorectal liver metastases: A phase II-study and historical comparison with the surgical approach
The high complication rates of surgically implanted port catheter systems (SIPCS) represents a major drawback in the treatment of isolated liver neoplasms by hepatic arterial infusion (HAI) of chemotherapy. In...
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Chapter
The Biologic Rationale of Hyperthermia
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Chapter
Interactions between Hyperthermia and Cytotoxic Drugs
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Article
Adjuvant chemotherapy with folinic acid and 5-fluorouracil in patients with locally advanced rectal cancer previously treated by preoperative radiochemotherapy and curative tumor resection
The role of postoperative adjuvant chemotherapy in patients with rectal cancer pretreated by preoperative radiochemotherapy (RCT) and curative surgery is still poorly investigated.
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Article
Open AccessGenetic dissection of apoptosis and cell cycle control in response of colorectal cancer treated with preoperative radiochemotherapy
In previous analyses we identified therapy-induced upregulation of the CDK inhibitor p21CIP/WAF-1 and consequently decreased tumor cell proliferation or loss of Bax as adverse factors for survival in rectal cance...
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Article
Open AccessA non-randomised, single-centre comparison of induction chemotherapy followed by radiochemotherapy versus concomitant chemotherapy with hyperfractionated radiotherapy in inoperable head and neck carcinomas
The application of induction chemotherapy failed to provide a consistent benefit for local control in primary treatment of advanced head and neck (H&N) cancers. The aim of this study was to compare the results...
