-
Article
Open AccessImpact of functional electrical stimulation on nerve-damaged muscles by quantifying fat infiltration using deep learning
Quantitative imaging in life sciences has evolved into a powerful approach combining advanced microscopy acquisition and automated analysis of image data. The focus of the present study is on the imaging-based...
-
Article
Open AccessLong-term stimulation by implanted pacemaker enables non-atrophic treatment of bilateral vocal fold paresis in a human-like animal model
A wide variety of treatments have been developed to improve respiratory function and quality of life in patients with bilateral vocal fold paresis (BVFP). One experimental method is the electrical activation o...
-
Article
Open AccessFactors Impacting Survival After Transarterial Radioembolization in Patients with Unresectable Intrahepatic Cholangiocarcinoma: A Combined Analysis of the Prospective CIRT Studies
Transarterial radioembolization (TARE) with Yttrium-90 resin microspheres is a treatment option for patients with intrahepatic cholangiocarcinoma (ICC). However, optimising the timing of TARE in relation to sy...
-
Article
Open AccessGerman, Austrian, and Swiss guidelines for systemic treatment of gastric cancer
The updated edition of the German, Austrian and Swiss Guidelines for Systemic Treatment of Gastric Cancer was completed in August 2023, incorporating new evidence that emerged after publication of the previous...
-
Article
Open AccessPredictive Factors for Adverse Event Outcomes After Transarterial Radioembolization with Yttrium-90 Resin Microspheres in Europe: Results from the Prospective Observational CIRT Study
Using data collected in the prospective observational study CIRSE Registry for SIR-Spheres Therapy, the present study aimed at identifying predictors of adverse events (AEs) following transarterial radioemboli...
-
Article
Open AccessComparison of machine learning methods with logistic regression analysis in creating predictive models for risk of critical in-hospital events in COVID-19 patients on hospital admission
Machine learning (ML) algorithms have been trained to early predict critical in-hospital events from COVID-19 using patient data at admission, but little is known on how their performance compares with each ot...
-
Article
Arbeitsgruppen zu kolorektalen Tumoren der AIO, der ACO und der ARO – „past, present, and future“
-
Living Reference Work Entry In depth
Media Policy in Hybrid Media Systems
Media systems in our time can be described with Chadwick (The hybrid media system. Politics and power. Oxford University Press, 2013) as hybrid, as characterized by a coexistence of “old” and “new” media. The ...
-
Article
Open AccessMicrosatellite instability (MSI-H) is associated with a high immunoscore but not with PD-L1 expression or increased survival in patients (pts.) with metastatic colorectal cancer (mCRC) treated with oxaliplatin (ox) and fluoropyrimidine (FP) with and without bevacizumab (bev): a pooled analysis of the AIO KRK 0207 and RO91 trials
In a retrospective analysis of two randomized phase III trials in mCRC patients treated first line with oxaliplatin, fluoropyrimidine with and without Bevacizumab (the AIO KRK 0207 and R091 trials) we evaluate...
-
Article
Open AccessHighlights from ASCO-GI 2021 from EORTC Gastrointestinal tract cancer group
Last year the field of immunotherapy was finally introduced to GI oncology, with several changes in clinical practice such as advanced hepatocellular carcinoma or metastatic colorectal MSI-H. At the virtual AS...
-
Reference Work Entry In depth
Calibration of Radioactive Sources
Detector systems for the measurement of radioactivity in various fields of applications need to be calibrated in terms of efficiency by means of radioactive sources of a given radionuclide with known activity....
-
Article
Open AccessShort-term Safety and Quality of Life Outcomes Following Radioembolization in Primary and Secondary Liver Tumours: a Multi-centre Analysis of 200 Patients in France
Radioembolization has emerged as a treatment modality for patients with primary and secondary liver tumours. This observational study CIRT-FR (CIRSE Registry for SIR-Spheres Therapy in France) aims to evaluate...
-
Article
Open AccessThe CIREL Cohort: A Prospective Controlled Registry Studying the Real-Life Use of Irinotecan-Loaded Chemoembolisation in Colorectal Cancer Liver Metastases: Interim Analysis
Transarterial chemoembolisation (TACE) using irinotecan-eluting beads is an additional treatment option for colorectal cancer liver metastases (CRLM) patients that are not eligible for curative treatment appro...
-
Article
Open AccessClinical Application of Trans-Arterial Radioembolization in Hepatic Malignancies in Europe: First Results from the Prospective Multicentre Observational Study CIRSE Registry for SIR-Spheres Therapy (CIRT)
To address the lack of prospective data on the real-life clinical application of trans-arterial radioembolization (TARE) in Europe, the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) ...
-
Article
Grundlagen der Immuntherapie
Immuntherapie bei malignen Erkrankungen ist definiert als ein systemtherapeutischer Ansatz, der auf die Fähigkeit des körpereigenen Immunsystems abzielt, die Entstehung von malignen Tumoren zu verhindern, bzw....
-
Chapter
Medienpolitik in hybriden Mediensystemen
Mediensysteme in unserer Zeit können mit Chadwick (2013) als hybrid bezeichnet werden, als geprägt von einem Neben- und Miteinander „alter“ und „neuer“ Medien. Gleiches gilt für die Medienpolitik. Digitalisier...
-
Living Reference Work Entry In depth
Calibration of Radioactive Sources
Detector systems for the measurement of radioactivity in various fields of applications need to be calibrated in terms of efficiency by means of radioactive sources of a given radionuclide with known activity....
-
Article
Open AccessImpact of primary tumour location on efficacy of bevacizumab plus chemotherapy in metastatic colorectal cancer
Two first-line (1L) bevacizumab trials showed the prognostic value of primary tumour location in metastatic colorectal cancer (mCRC). In this retrospective subgroup analysis, further analysis of the predictive...
-
Article
MODUL—a multicenter randomized clinical trial of biomarker-driven maintenance therapy following first-line standard induction treatment of metastatic colorectal cancer: an adaptable signal-seeking approach
The old approach of one therapeutic for all patients with mCRC is evolving with a need to target specific molecular aberrations or cell-signalling pathways. Molecular screening approaches and new biomarkers ar...
-
Chapter and Conference Paper
Neuromechanical Model of Rat Hind Limb Walking with Two Layer CPGs and Muscle Synergies
We present a synthetic nervous system modeling mammalian locomotion using separate central pattern generator and pattern formation layers. The central pattern generator defines the rhythm of locomotion and the...
