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Open AccessMechanical stimulation and electrophysiological monitoring at subcellular resolution reveals differential mechanosensation of neurons within networks
A growing consensus that the brain is a mechanosensitive organ is driving the need for tools that mechanically stimulate and simultaneously record the electrophysiological response of neurons within neuronal n...
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Open AccessAuthor Correction: Highly specific and non-invasive imaging of Piezo1-dependent activity across scales using GenEPi
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Article
Open AccessHighly specific and non-invasive imaging of Piezo1-dependent activity across scales using GenEPi
Mechanosensing is a ubiquitous process to translate external mechanical stimuli into biological responses. Piezo1 ion channels are directly gated by mechanical forces and play an essential role in cellular mec...
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Article
Open AccessRestoration of high-sensitivity and adapting vision with a cone opsin
Inherited and age-related retinal degenerative diseases cause progressive loss of rod and cone photoreceptors, leading to blindness, but spare downstream retinal neurons, which can be targeted for optogenetic ...
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Article
Atomic force microscopy-based mechanobiology
Mechanobiology emerges at the crossroads of medicine, biology, biophysics and engineering and describes how the responses of proteins, cells, tissues and organs to mechanical cues contribute to development, di...
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Article
Open AccessAuthor Correction: Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor
Kevin J. Cao and Richard H. Kramer, who developed extended release with beta cyclodextrin, were inadvertently omitted from the author list and author contributions section of this Article. These errors have no...
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Protocol
Optogenetic Retinal Gene Therapy with the Light Gated GPCR Vertebrate Rhodopsin
In retinal disease, despite the loss of light sensitivity as photoreceptors die, many retinal interneurons survive in a physiologically and metabolically functional state for long periods. This provides an opp...
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Article
Open AccessRestoration of patterned vision with an engineered photoactivatable G protein-coupled receptor
Retinitis pigmentosa results in blindness due to degeneration of photoreceptors, but spares other retinal cells, leading to the hope that expression of light-activated signaling proteins in the surviving cells...
