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  1. Article

    Open Access

    Prospective study validating a multidimensional treatment decision score predicting the 24-month outcome in untreated patients with clinically isolated syndrome and early relapsing–remitting multiple sclerosis, the ProVal-MS study

    In Multiple Sclerosis (MS), patients´ characteristics and (bio)markers that reliably predict the individual disease prognosis at disease onset are lacking. Cohort studies allow a close follow-up of MS historie...

    Antonios Bayas, Ulrich Mansmann, Begum Irmak Ön in Neurological Research and Practice (2024)

  2. Article

    Open Access

    Regional computed tomography perfusion deficits in patients with hypoglycemia: two case reports

    Hypoglycemia in patients with diabetes mellitus, particularly type 1 can mimic acute ischemic stroke by causing focal neurological deficits. In acute ischemic stroke, the interpretation of emergency imaging in...

    Jennifer Sartor-Pfeiffer, Mirjam Lingel in Neurological Research and Practice (2022)

  3. Article

    Open Access

    T2-Pseudonormalization and Microstructural Characterization in Advanced Stages of Late-infantile Metachromatic Leukodystrophy

    T2-weighted signal hyperintensities in white matter (WM) are a diagnostic finding in brain magnetic resonance imaging (MRI) of patients with metachromatic leukodystrophy (MLD). In our systematic investigation ...

    Pascal Martin, Gisela E. Hagberg, Thomas Schultz, Klaus Harzer in Clinical Neuroradiology (2021)

  4. Article

    Open Access

    Correction to: Association of dynamic susceptibility magnetic resonance imaging at initial tumor diagnosis with the prognosis of different molecular glioma subtypes

    A Correction to this paper has been published: https://doi.org/10.1007/s10072-021-05352-6

    Cornelia Brendle, Uwe Klose, Johann-Martin Hempel in Neurological Sciences (2021)

  5. No Access

    Article

    Technical limitations and pitfalls of diffusion-weighted imaging in intraoperative high-field MRI

    Objective: Image quality in high-field intraoperative MRI (iMRI) is often influenced negatively by susceptibility artifacts. While routine sequences are rather robust, advanced imaging such as diffusion-weight...

    Constantin Roder, Patrick Haas, Marcos Tatagiba, Ulrike Ernemann in Neurosurgical Review (2021)

  6. Article

    Open Access

    Association of dynamic susceptibility magnetic resonance imaging at initial tumor diagnosis with the prognosis of different molecular glioma subtypes

    The updated 2016 CNS World Health Organization classification differentiates three main groups of diffuse glioma according to their molecular characteristics: astrocytic tumors with and without isocitrate dehy...

    Cornelia Brendle, Uwe Klose, Johann-Martin Hempel in Neurological Sciences (2020)

  7. No Access

    Article

    Identification of tumor residuals in pituitary adenoma surgery with intraoperative MRI: do we need gadolinium?

    To evaluate the diagnostic accuracy of high-resolution T2w intraoperative magnetic resonance imaging (iMRI) for detecting pituitary adenoma remnants compared to contrast-enhanced T1-weighted images.

    Georg Gohla, Benjamin Bender, Marcos Tatagiba, Jürgen Honegger in Neurosurgical Review (2020)

  8. No Access

    Article

    Automatic volumetry of cerebrospinal fluid and brain volume in severe paediatric hydrocephalus, implementation and clinical course after intervention

    In childhood hydrocephalus, both the amount of cerebrospinal fluid and the brain volume are relevant for the prognosis of the development and for therapy monitoring. Since classical planar measurements of vent...

    Florian Grimm, Florian Edl, Isabel Gugel, Susanne R. Kerscher in Acta Neurochirurgica (2020)

  9. No Access

    Article

    In Vivo Molecular Profiling of Human Glioma

    To assess the diagnostic performance of dynamic susceptibility contrast perfusion magnetic resonance perfusion imaging (DSC-MRI) for in vivo human glioma molecular profiling.

    Johann-Martin Hempel, Jens Schittenhelm, Uwe Klose in Clinical Neuroradiology (2019)

  10. No Access

    Article

    Ki-67 labeling index and expression of p53 are non-predictive for invasiveness and tumor size in functional and nonfunctional pituitary adenomas

    It is still controversial whether an increased proliferation index is correlated with the tumor invasiveness of pituitary adenomas. A homogeneous large monocentric series of pituitary adenomas was retrospectiv...

    Florian Grimm, Roland Maurus, Rudi Beschorner, Georgios Naros in Acta Neurochirurgica (2019)

  11. No Access

    Article

    Effect of Perfusion on Diffusion Kurtosis Imaging Estimates for In Vivo Assessment of Integrated 2016 WHO Glioma Grades

    To assess the role of perfusion-related signal decay on diffusion kurtosis imaging (DKI) estimates for in vivo stratification of glioma according to the integrated approach of the 2016 World Health Organizatio...

    Johann-Martin Hempel, Jens Schittenhelm, Cornelia Brendle in Clinical Neuroradiology (2018)

  12. No Access

    Article

    Glioma Grading and Determination of IDH Mutation Status and ATRX loss by DCE and ASL Perfusion

    To evaluate arterial spin labeling (ASL) perfusion and dynamic contrast-enhanced (DCE) perfusion in glioma grading according to the previous WHO classification of 2007, as well as concerning isocitrate dehydro...

    Cornelia Brendle, Johann-Martin Hempel, Jens Schittenhelm in Clinical Neuroradiology (2018)

  13. No Access

    Article

    Glioma grading by dynamic susceptibility contrast perfusion and 11C-methionine positron emission tomography using different regions of interest

    The use of dynamic susceptibility contrast (DSC) perfusion and 11C-methionine positron emission tomography (MET-PET) for glioma grading is currently not standardized. The purpose of this study was to identify reg...

    Cornelia Brendle, Johann-Martin Hempel, Jens Schittenhelm in Neuroradiology (2018)

  14. No Access

    Article

    Optimized depiction of thalamic substructures with a combination of T1-MPRAGE and phase: MPRAGE*

    Deep brain stimulation has received increasing attention in recent years as a treatment option for many neurological diseases. The thalamic nuclei in particular are widely used as targets. The goal of the pres...

    Benjamin Bender, Stefan Wagner, Uwe Klose in Clinical Neuroradiology (2017)

  15. No Access

    Article

    Enhanced gray-white matter differentiation on non-enhanced CT using a frequency selective non-linear blending

    The aim if this study is to find out if contrast between gray (GM) and white matter (WM) on non-enhanced brain CT (NECT) can be enhanced by using a frequency selective non-linear blending.

    Georg Bier, Malte Niklas Bongers, Hendrik Ditt, Benjamin Bender in Neuroradiology (2016)

  16. No Access

    Article

    The regional distribution of T2-relaxation times in MR images of the substantia nigra and crus cerebri

    When scanning the size of the substantia nigra (SN), for example in Parkinson's disease, it is important to precisely locate its true anatomic location. The hypointense areas on T2-weighted magnetic resonance ...

    Constantin Mänz, Jana Godau, Daniela Berg, Benjamin Bender in Neuroradiology (2010)