46 Result(s)

Article

An MRI evaluation of white matter involvement in paradigmatic forms of spastic ataxia: results from the multi-center PROSPAX study

Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) and Spastic Paraplegia Type 7 (SPG7) are paradigmatic spastic ataxias (SPAX) with suggested white matter (WM) involvement. Aim of this work wa...

Alessandra Scaravilli, Ilaria Gabusi, Gaia Mari, Matteo Battocchio… in Journal of Neurology (2024)

Article

Prospective study validating a multidimensional treatment decision score predicting the 24-month outcome in untreated patients with clinically isolated syndrome and early relapsing–remitting multiple sclerosis, the ProVal-MS study

In Multiple Sclerosis (MS), patients´ characteristics and (bio)markers that reliably predict the individual disease prognosis at disease onset are lacking. Cohort studies allow a close follow-up of MS historie...

Antonios Bayas, Ulrich Mansmann, Begum Irmak Ön… in Neurological Research and Practice (2024)

Article

Ready for testing artificial intelligence in radiology clinical practice: We would do well to be in the front line leveraging their strengths but also highlighting today weaknesses

Benjamin Bender in European Radiology (2024)

Article

Fronto-striatal alterations correlate with apathy severity in behavioral variant frontotemporal dementia

Structural and functional changes in cortical and subcortical regions have been reported in behavioral variant frontotemporal dementia (bvFTD), however, a multimodal approach may provide deeper insights into t...

Neeraj Upadhyay, Annika Spottke, Anja Schneider… in Brain Imaging and Behavior (2024)

Article

Patterns of acute ischemic stroke and intracranial hemorrhage in patients with COVID-19

Coronavirus disease 2019 (COVID-19) is an infection which can affect the central nervous system. In this study, we sought to investigate associations between neuroimaging findings with clinical, demographic, b...

Ulf Jensen-Kondering, Christoph J. Maurer, Hanna C. B. Brudermann… in Journal of Neurology (2023)

Article

Big Field of View MRI T1w and FLAIR Template - NMRI225

Image templates are a common tool for neuroscience research. Often, they are used for spatial normalization of magnetic resonance imaging (MRI) data, which is a necessary procedure for analyzing brain morpholo...

Barbara A. K. Kreilkamp, Pascal Martin, Benjamin Bender… in Scientific Data (2023)

Article

Proof of principle for the clinical use of a CE-certified automatic imaging analysis tool in rare diseases studying hereditary spastic paraplegia type 4 (SPG4)

Usage of MR imaging biomarkers is limited to experts. Automatic quantitative reports provide access for clinicians to data analysis. Automated data analysis was tested for usability in a small cohort of patien...

Tobias Lindig, Benjamin Bender, Eva Bürkle, Vinod Kumar… in Scientific Reports (2022)

Article

Linking the phenotype of SNCA Triplication with PET-MRI imaging pattern and alpha-synuclein CSF seeding

Lewy-body pathology with aggregation of abnormal conformations of the protein alpha-synuclein (α-Syn) represent the histopathological hallmarks of Parkinson’s disease (PD). Genetic prototypes such as PD due to...

Isabel Wurster, Corinne Quadalti, Marcello Rossi… in npj Parkinson's Disease (2022)

Article

Regional computed tomography perfusion deficits in patients with hypoglycemia: two case reports

Hypoglycemia in patients with diabetes mellitus, particularly type 1 can mimic acute ischemic stroke by causing focal neurological deficits. In acute ischemic stroke, the interpretation of emergency imaging in...

Jennifer Sartor-Pfeiffer, Mirjam Lingel… in Neurological Research and Practice (2022)

Article

GLINT: GlucoCEST in neoplastic tumors at 3 T—clinical results of GlucoCEST in gliomas

Clinical relevance of dynamic glucose enhanced (DGE) chemical exchange saturation transfer (CEST) imaging has mostly been demonstrated at ultra-high field (UHF) due to low effect size. Results of a cohort stud...

Benjamin Bender, Kai Herz, Anagha Deshmane… in Magnetic Resonance Materials in Physics, B… (2022)

Article

What do we know about dynamic glucose-enhanced (DGE) MRI and how close is it to the clinics? Horizon 2020 GLINT consortium report

Cancer is one of the most devastating diseases that the world is currently facing, accounting for 10 million deaths in 2020 (WHO). In the last two decades, advanced medical imaging has played an ever more impo...

Mina Kim, Afroditi Eleftheriou, Luca Ravotto… in Magnetic Resonance Materials in Physics, B… (2022)

Article

T2-Pseudonormalization and Microstructural Characterization in Advanced Stages of Late-infantile Metachromatic Leukodystrophy

T2-weighted signal hyperintensities in white matter (WM) are a diagnostic finding in brain magnetic resonance imaging (MRI) of patients with metachromatic leukodystrophy (MLD). In our systematic investigation ...

Pascal Martin, Gisela E. Hagberg, Thomas Schultz, Klaus Harzer… in Clinical Neuroradiology (2021)

Article

Correction to: Association of dynamic susceptibility magnetic resonance imaging at initial tumor diagnosis with the prognosis of different molecular glioma subtypes

A Correction to this paper has been published: https://doi.org/10.1007/s10072-021-05352-6

Cornelia Brendle, Uwe Klose, Johann-Martin Hempel… in Neurological Sciences (2021)

Article

Retrospective analysis of recurrence patterns and clinical outcome of grade II meningiomas following postoperative radiotherapy

Atypical meningiomas exhibit a high tendency for tumor recurrence even after multimodal therapy. Information regarding recurrence patterns after additive radiotherapy is scarce but could improve radiotherapy p...

Elgin Hoffmann, Kerstin Clasen, Bettina Frey, Jakob Ehlers… in Radiation Oncology (2021)

Article

Cortical and subcortical gray matter changes in patients with chronic tinnitus sustaining after vestibular schwannoma surgery

Tinnitus is attributed to partial sensory deafferentation resulting in a central maladaptive neuroplasticity. Unfortunately, the agent of deafferentation is usually unknown or irreversible. In patients with un...

Leonidas Trakolis, Benjamin Bender, Florian H. Ebner, Ulrike Ernemann… in Scientific Reports (2021)

Article

Association of dynamic susceptibility magnetic resonance imaging at initial tumor diagnosis with the prognosis of different molecular glioma subtypes

The updated 2016 CNS World Health Organization classification differentiates three main groups of diffuse glioma according to their molecular characteristics: astrocytic tumors with and without isocitrate dehy...

Cornelia Brendle, Uwe Klose, Johann-Martin Hempel… in Neurological Sciences (2020)

Article

Correction to: Retrospective analysis of fractionated intensity-modulated radiotherapy (IMRT) in the interdisciplinary management of primary optic nerve sheath meningiomas

An amendment to this paper has been published and can be accessed via the original article.

Franziska Eckert, Kerstin Clasen, Carina Kelbsch, Felix Tonagel… in Radiation Oncology (2020)

Article

Early clinical course after hematopoietic stem cell transplantation in children with juvenile metachromatic leukodystrophy

Long-term outcomes of hematopoietic stem cell transplantation (HSCT) in children with juvenile metachromatic leukodystrophy (MLD) have been investigated systematically, while short-term effects of HSCT on the ...

Judith Beschle, Michaela Döring, Christiane Kehrer… in Molecular and Cellular Pediatrics (2020)