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Article
Open AccessPositive buttress reduction in femoral neck fractures: a literature review
Femoral neck fractures (FNFs) in young adults are usually caused by high-energy trauma, and their treatment remains a challenging issue for orthopedic surgeons. The quality of reduction is considered an import...
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Article
Open AccessTranexamic versus aminocaproic acids in patients with total hip arthroplasty: a retrospective study
Recently, tranexamic acid (TXA) and epsilon aminocaproic acid (EACA) have been applied in total hip arthroplasty (THA). However, doubts in clinicians’ minds about which medicine is more efficient and economica...
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Article
Bioequivalence of nifedipine softgel and capsule in healthy Chinese volunteers by liquid chromatography–mass spectrometry
The study aimed to compare and evaluate the bioequivalence of Calcigard-10 softgel and Adalat® 10 capsule in healthy Chinese volunteers in a randomized, two-way cross over study design with a washout period of 7 ...
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Article
Development and validation of a sensitive LC-MS method for the determination of tramadol in human plasma and urine
A sensitive and selective liquid chromatography-tandem mass spectrometric (LC-MS) method was developed and validated for the determination of Tramadol in human plasma and urine. The analyte was separated on a ...
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Article
Development and validation of a sensitive LC-MS method for the determination of Promethazine hydrochloride in human plasma and urine
We developed and validated a sensitive and low sample volume liquid chromatographic-mass spectrometric (LC-MS) method for determination of Promethazine hydrochloride in human plasma (0.5 ml) or urine (0.1 ml)....
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Article
Pharmacokinetics, safety and tolerance of single- and multiple-dose of a novel compound tramadol hydrochloride injection (35 mg tramadol hydrochloride, 45 mgl promethazine hydrochloride) in Chinese healthy subjects
The pharmacokinetics of Tramadol and Promethazine after a single dose of 40, 80 and 120 mg intramuscular injecting CTHI was evaluated in healthy volunteers. Physical exam, vital signs, clinical laboratory test...
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Article
Construction of expression system of rabbit aldehyde oxidase cDNA for the clarification of species differences
A remarkably large species difference in cinchonidine oxidation activity catalyzed by aldehyde oxidase (AO) has been known, in particular between rabbit and monkey. As the first step in clarifying the phenomen...
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Article
An improved HPLC method for determination of nifuratel in human plasma and its application to pharmacokinetics studies
A rapid, simple and sensitive high-performance liquid chromatography (HPLC) method was established for the quantification of nifuratel in human plasma and applied to a study of its pharmacokinetics. A test and...