5 Result(s)

Article

Base editing-mediated one-step inactivation of the Dnmt gene family reveals critical roles of DNA methylation during mouse gastrulation

During embryo development, DNA methylation is established by DNMT3A/3B and subsequently maintained by DNMT1. While much research has been done in this field, the functional significance of DNA methylation in e...

Qing Li, Jiansen Lu, **di Yin, Yunjian Chang, Chao Wang, Meng Yan… in Nature Communications (2023)

Article

Single-cell CAS-seq reveals a class of short PIWI-interacting RNAs in human oocytes

Small RNAs have important functions. However, small RNAs in primate oocytes remain unexplored. Herein, we develop CAS-seq, a single-cell small RNA sequencing method, and profile the small RNAs in human oocytes...

Qiyuan Yang, Ronghong Li, Qifeng Lyu, Li Hou, Zhen Liu, Qiang Sun… in Nature Communications (2019)

Article

Identification of small non-coding RNAs as sperm quality biomarkers for in vitro fertilization

Minmin Hua, Wei Liu, Ying Chen, Fengjuan Zhang, Beiying Xu, Suying Liu… in Cell Discovery (2019)

Article

Ribozyme-enhanced single-stranded Ago2-processed interfering RNA triggers efficient gene silencing with fewer off-target effects

Short-hairpin RNAs (shRNAs) are widely used to produce small-interfering RNAs (siRNAs) for gene silencing. Here we design an alternative siRNA precursor, named single-stranded, Argonaute 2 (Ago2)-processed int...

Renfu Shang, Fengjuan Zhang, Beiying Xu, Hairui **, Xue Zhang… in Nature Communications (2015)