364 Result(s)
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English
Science, Humanities and Social Sciences, multidisciplinary
Science, Humanities and Social Sciences, multidisciplinary
Bei **
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Article
Open AccessFolding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone
Cytosolic HSP90 requires multiple cochaperones in folding client proteins. However, the function of gp96 (HSP90b1, grp94), an HSP90 paralogue in the endoplasmic reticulum (ER), is believed to be independent of...
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Open AccessKnockdown of MRP4 by lentivirus-mediated siRNA improves sensitivity to adriamycin in adriamycin-resistant acute myeloid leukemia cells
Chemotherapy remains the standard treatment for acute myeloid leukemia; however, the emergence of drug resistance is a major hurdle in the successful treatment of leukemia. The expression of multidrug resistan...
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Erratum: Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone
Nature Communications 1: Article number: 79 (2010); Published: 21 September 2010; Updated: 31 January 2012. The image in Figure 5d of this Article was inadvertently duplicated from panel e. The correct version...
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Open AccessNitrogen-doped graphene: beyond single substitution and enhanced molecular sensing
Graphene is a two-dimensional network in which sp2-hybridized carbon atoms are arranged in two different triangular sub-lattices (A and B). By incorporating nitrogen atoms into graphene, its physico-chemical prop...
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Open AccessRemobilization of heavy metals during the resuspension of Liangshui River sediments using an annular flume
The release and transport of heavy metals (Ni, Cr, Cu and Pb) from Liangshui River sediments into the overlying water column during the resuspension event were determined using an annular flume with a velocity...
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Open AccessUse of Direct Gradient Analysis to Uncover Biological Hypotheses in 16S Survey Data and Beyond
This study investigated the use of direct gradient analysis of bacterial 16S pyrosequencing surveys to identify relevant bacterial community signals in the midst of a "noisy" background and to facilitate hypot...
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Open AccessA proton shelter inspired by the sugar coating of acidophilic archaea
The acidophilic archaeons are a group of single-celled microorganisms that flourish in hot acid springs (usually pH < 3) but maintain their internal pH near neutral. Although there is a lack of direct evidence...
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Open AccessStandard molar enthalpy of combustion and formation of quaternary ammonium tetrachlorozincate [n-CnH2n+1 N(CH3)3]2 ZnCl4
The standard molar enthalpy of combustion (Δc H o m) and formation (Δf H o m) of quaternary ammonium tetrachlorozincate [n-CnH2n+1N(CH3)3]2ZnCl4 have been determined for the hydrocarbon chain length from even num...
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Open AccessIdentification of individual and few layers of WS2 using Raman Spectroscopy
The Raman scattering of single- and few-layered WS2 is studied as a function of the number of S-W-S layers and the excitation wavelength in the visible range (488, 514 and 647 nm). For the three excitation wavele...
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Open AccessS-nitrosylation of ERK inhibits ERK phosphorylation and induces apoptosis
Extracellular signal-regulated kinase (ERK) belongs to the mitogen-activated protein kinases (MAPK) superfamily. Aberrant upregulation and activation of ERK cascades may often lead to tumor cell development. H...
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Open AccessPhysiologically-Relevant Modes of Membrane Interactions by the Human Antimicrobial Peptide, LL-37, Revealed by SFG Experiments
Antimicrobial peptides (AMPs) could become the next generation antibiotic compounds which can overcome bacterial resistance by disrupting cell membranes and it is essential to determine the factors underlying ...
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Open Accessp53 increases MHC class I expression by upregulating the endoplasmic reticulum aminopeptidase ERAP1
The p53 tumour suppressor has an important role in cancer cells. Here we show that p53 regulates expression of major histocompatibility complex I on the cell surface. We show that the tumour cell line HCT116, ...
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Open AccessStructural and chronological constraints on a Late Paleozoic shortening event in the Yanshan Tectonic Belt
Early deformation history of the Yanshan Tectonic Belt is an unsolved, important issue. We report early structures and their dating results in basement rocks south of the Kalaqin metamorphic core complex. The ...
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Open AccessNew Observations and Insights into the Morphology and Growth Kinetics of Hydrate Films
The kinetics of film growth of hydrates of methane, ethane and methane-ethane mixtures were studied by exposing a single gas bubble to water. The morphologies, lateral growth rates and thicknesses of the hydra...
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Open AccessGenetic variant in SWI/SNF complexes influences hepatocellular carcinoma risk: a new clue for the contribution of chromatin remodeling in carcinogenesis
Chromatin remodeling has been newly established as an important cancer genome characterization and recent exome and whole-genome sequencing studies of hepatocellular carcinoma (HCC) showed that recurrent inact...
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Open AccessA meta-analysis of olanzapine for the prevention of chemotherapy-induced nausea and vomiting
Chemotherapy-induced nausea and vomiting (CINV) is associated with a significant deterioration in quality of life and is one of the reasons for the discontinuation of treatment. Olanzapine is known as an atypi...
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Open AccessAnalysis of horse genomes provides insight into the diversification and adaptive evolution of karyotype
Karyotypic diversification is more prominent in Equus species than in other mammals. Here, using next generation sequencing technology, we generated and de novo assembled quality genomes sequences for a male wild...
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Open AccessNew insight into the spin-conserving excitation of the negatively charged nitrogen-vacancy center in diamond
The negatively charged nitrogen-vacancy (N-V−) color center in diamond is an important solid-state single photon source for applications to quantum communication and distributed quantum computation. Its full usef...
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Open AccessAll-optical regulation of gene expression in targeted cells
Controllable gene expression is always a challenge and of great significance to biomedical research and clinical applications. Recently, various approaches based on extra-engineered light-sensitive proteins ha...
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Open AccessDynamics of inflammation resolution and symptom recovery during AECOPD treatment
The association between increases in both systemic and airway inflammation and acute exacerbation of COPD (AECOPD) has been reported by many studies. However, relatively little is known about the dynamics of i...
