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Article
Open AccessHaptoglobin Attenuates Cerebrospinal Fluid Hemoglobin-Induced Neurological Deterioration in Sheep
Secondary brain injury (SBI) occurs with a lag of several days post-bleeding in patients with aneurysmal subarachnoid hemorrhage (aSAH) and is a strong contributor to mortality and long-term morbidity. aSAH-S...
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Article
Ultrasound guidance in navigated liver surgery: toward deep-learning enhanced compensation of deformation and organ motion
Accuracy of image-guided liver surgery is challenged by deformation of the liver during the procedure. This study aims at improving navigation accuracy by using intraoperative deep learning segmentation and no...
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Article
Open AccessMyD88-TLR4-dependent choroid plexus activation precedes perilesional inflammation and secondary brain edema in a mouse model of intracerebral hemorrhage
The functional neurological outcome of patients with intracerebral hemorrhage (ICH) strongly relates to the degree of secondary brain injury (ICH-SBI) evolving within days after the initial bleeding. Different...
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Article
Ultrasound-based navigation for open liver surgery using active liver tracking
Despite extensive preoperative imaging, intraoperative localization of liver lesions after systemic treatment can be challenging. Therefore, an image-guided navigation setup is explored that links preoperative...
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Article
Open AccessThe HeMoVal study protocol: a prospective international multicenter cohort study to validate cerebrospinal fluid hemoglobin as a monitoring biomarker for aneurysmal subarachnoid hemorrhage related secondary brain injury
Preclinical studies provided a strong rationale for a pathophysiological link between cell-free hemoglobin in the cerebrospinal fluid (CSF-Hb) and secondary brain injury after subarachnoid hemorrhage (SAH-SBI)...
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Chapter and Conference Paper
MR-to-US Registration Using Multiclass Segmentation of Hepatic Vasculature with a Reduced 3D U-Net
Accurate hepatic vessel segmentation and registration using ultrasound (US) can contribute to beneficial navigation during hepatic surgery. However, it is challenging due to noise and speckle in US imaging and...
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Article
Open AccessPhysics-informed Deep Learning for Dual-Energy Computed Tomography Image Processing
Dual-energy CT (DECT) was introduced to address the inability of conventional single-energy computed tomography (SECT) to distinguish materials with similar absorbances but different elemental compositions. Ho...
