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Article
Open AccessDesmoglein 2 and desmocollin 2 depletions promote malignancy through distinct mechanisms in triple-negative and luminal breast cancer
Aberrant expressions of desmoglein 2 (Dsg2) and desmocollin 2(Dsc2), the two most widely distributed desmosomal cadherins, have been found to play various roles in cancer in a context-dependent manner. Their s...
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Article
Open AccessMicroRNA-506 is up-regulated in the development of pancreatic ductal adenocarcinoma and is associated with attenuated disease progression
MicroRNA-506 (miR-506) has been reported to function in several tumors as a tumor suppressor gene or oncogene. However, the expression and role of miR-506 in pancreatic ductal adenocarcinoma (PDAC) remains unc...
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Article
Open AccessKey nodes of a microRNA network associated with the integrated mesenchymal subtype of high-grade serous ovarian cancer
Metastasis is the main cause of cancer mortality. One of the initiating events of cancer metastasis of epithelial tumors is epithelial-to-mesenchymal transition (EMT), during which cells dedifferentiate from a...
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Article
Hypoxia-induced vasculogenic mimicry formation via VE-cadherin regulation by Bcl-2
Vasculogenic mimicry (VM) refers to the unique ability of highly aggressive tumor cells to mimic the pattern of embryonic vasculogenic networks. Hypoxia plays a pivotal role in the formation of VM. Hypoxia-ind...
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Article
Coexpression of Bcl-2 with epithelial–mesenchymal transition regulators is a prognostic indicator in hepatocellular carcinoma
The anti-apoptosis factor Bcl-2 is known to contribute to tumorigenesis and metastasis. Epithelial–mesenchymal transition (EMT) may also participate in tumor invasion and metastasis. This study investigated th...
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Article
Predictive value of circulating endothelial cells for efficacy of chemotherapy with Rh-endostatin in non-small cell lung cancer
The present study was designed to elucidate the fluctuation of activated CECs (aCECs) during different therapies and to investigate their predictive value for efficacy of anti-angiogenesis and chemotherapy in ...
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Article
Study of the correlation of EGFR and K-RAS gene mutations with its protein expression in non-small cell lung cancer
To investigate gene mutations of epidermal growth factor receptor (EGFR) and K-RAS (Kirsten rat sarcoma viral oncogene) in Chinese patients with non-small cell lung cancer (NSCLC), and study the correlation wi...
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Article
Expression of coxsackievirus and adenovirus receptor in human lung cancer: Possible clinical significance
To explore the relationship between CAR and the development of human lung cancer, as well as to provide the basis for the clinical treatment of lung cancer using an adenovirus vector-based gene therapy.
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Article
Open AccessA pilot study on acute inflammation and cancer: a new balance between IFN-γ and TGF-β in melanoma
Recent data have redefined the concept of inflammation as a critical component of tumor progression. However, there has been little development on cases where inflammation on or near a wound and a tumor exist ...
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Chapter
Regulation of Motor Behavior by Dopamine Receptor Subtypes
The neurotransmitter dopamine mediates various behavioral functions in the central nervous system (CNS). The major dopamine pathway involved in motor function is the nigrostriatal pathway, which originates fro...
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Chapter
Electrophysiological Consequences of D2 and/or D3 Receptor Knockout by Antisense Oligonucleotides in Nigrostriatal Dopaminergic Neurons
Mesencephalic dopaminergic neurons possess receptors for their own neurotransmitter, dopamine, at both somatodendritic as well as axon terminal regions. These receptors are termed autoreceptors and act to modu...
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Chapter
Neuropharmacological Effects of (−)-Stepholidine and its Analogues on Brain Dopaminergic System
Tetrahydroprotoberberines (THPBs), a series of natural products isolated from the Chinese herbs Corydalis and Stephania, have been proven to be novel dopamine (DA) receptor antagonists, among them, (-)-stephol...
