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Article
Rapid separation of elemental species by multicapillary GC
Multicapillary gas chromatography has been applied to the speciation of organomercury compounds. Basic investigation of the fundamental properties of multicapillary columns, to evaluate their potential and li...
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Article
35th Annual Meeting of the European Association for the Study of Diabetes
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Article
Pharmacokinetics and safety of glimepiride at clinically effective doses in diabetic patients with renal impairment
The pharmacokinetics, efficacy and safety of glimepiride were investigated in a single- and a multiple-dose open study in patients with non-insulin-dependent diabetes mellitus and renal impairment and an init...
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Article
Die obstipierende Wirkung der Opioide Tilidin-N und Tramadol im Vergleich zu Codein
Tramadol, ein mittelstark wirkendes Opioid, führt neben einer Bindung am Opioidrezeptor, zusätzlich zu einer Wiederaufnahmehemmung monominerger Transmitter. Ähnlich wie von den Opioiden Tilidin/Naloxon und Cod...
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Article
Metamizole-furosemide interaction study in healthy volunteers
The pharmacokinetic and pharmacodynamic interactions between metamizole (dipyrone) and furosemide were investigated in 9 of 12 healthy female subjects able to complete the study. They received oral metamizole ...
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Chapter and Conference Paper
The use of OKT3 in steroid-resistant rejections following cadaveric kidney transplantation
OKT3 has been proved to be effective in the treatment of steroid-resistant rejection after renal allograft transplantation [1]. We investigated the clinical course of OKT3 recipients to find out in which cases...
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Article
Effect of pentoxifylline on liver plasma flow in normal man
In ten healthy, male subjects the acute effect of pentoxifylline (a methylxanthine derivative) on liver plasma flow was investigated by the extrarenal sorbitol clearance method and on cardiac output by impedan...
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Article
A Pharmacokinetic Study of Roxatidine Acetate in Chronic Renal Failure
The pharmacokinetics of a single oral dose of roxatidine acetate 150mg were studied in 31 patients with varying degrees of chronic renal failure. The patients were divided into 5 groups according to their crea...
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Chapter
Analysis of Eicosanoids by GC-MS/MS
Analysis of eicosanoids in biological matrices is difficult. Their levels are very low, and they are rapidly metabolized to numerous structurally similar substances often found in much higher concentration. He...
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Article
Famotidine, a new H2-receptor antagonist, does not affect hepatic elimination of diazepam or tubular secretion of procainamide
In 8 healthy male volunteers the pharmacodynamic responses to a single dose of diazepam and a single dose of procainamide were assessed before and after pre-treatment with the H2-receptor antagonist famotidine in...
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Article
Plasma levels of sulfinpyrazone and of two of its metabolites after a single dose and during the steady state
The pharmacokinetics of sulfinpyrazone, and the plasma levels of its sulfide and sulfone metabolites, have been determined after a single oral dose (400 mg) and during steady-state conditions (4×200 mg daily f...
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Chapter and Conference Paper
Klinische Pharmakologie
Seit vielen Jahren gehört Theophyllin zur Basismedikation der Behandlung der obstruktiven Komponente von Atemwegserkrankungen. Die weit verbreitete Anwendung dieses Medikamentes einerseits und die enge therape...
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Chapter and Conference Paper
Prostaglandins in Human Hypertension: Relationships to Renin, Sodium, and Antihypertensive Drug Action
Ever since pharmacologic experiments have shown the blood pressure-lowering effect of prostaglandins (PGs), attempts have been made to eludicate a role of endogenous PGs in regulation of blood pressure (for re...
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Chapter
Analysis of Prostanoids and their Metabolites by Gas Chromatography-Mass Spectrometry
The late discovery and evaluation of prostanoids can be explained in part by the special methods which are required for the isolation and detection of this class of compounds (1–7). Significant progress in bio...
