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Article
Protrahierter Verlauf einer Pertussiserkrankung im Erwachsenenalter
Pertussis (Keuchhusten) ist nicht nur eine Kinderkrankheit, sondern verursacht auch im Jugendlichen- und Erwachsenenalter lang andauernden Husten. Dennoch ist Pertussis normalerweise kein Bestandteil der Diffe...
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Chapter
Magnetische Resonanzangiographie (MRA)
Die von Bloch [12] und Purcell [106] 1946 entdeckte Kernspintomographie bekam erst medizinische Bedeutung, nachdem Lauterbur 1974 [77] reelle Möglichkeiten zur Bildgebung praktisch demonstriert hatte und Kumar...
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Article
Concentration-effect relationship of the positive chronotropic and hypokalaemic effects of fenoterol in healthy women of childbearing age
Objective: To analyse fenoterol-induced tachycardia and hypokalaemia, the most important and most frequent adverse effects of tocolytic therapy with β2-adrenoceptor agonists in females o...
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Article
Die Standardisierung der externen Tokographie. Anwendung des Verfahrens zum Nachweis der Wirksamkeit einer Langzeittokolyse
Zusammenfassend meinen wir also zeigen zu können, daß die externe Tokographie ein valides und reliables Messinstrument sein kann. Die intraindividuelle day-to-day Variabilität liegt in dem für derartige Method...
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Article
Pharmacokinetics of fenoterol in pregnant and nonpregnant women
The pharmacokinetics of the β2-adrenergic drug fenoterol, which is used as a tocolytic agent in pregnancy, has been investigated in pregnant (n=9) and nonpregnant (n=5) women during a constant rate intravenous in...
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Chapter and Conference Paper
Die Standardisierung der externen Tokographie. Anwendung des Verfahrens zum Nachweis der Wirksamkeit einer Langzeittokolyse
Die externe Tokographie ist die nichtinvasive Methode, mit der die Uterusaktivität in der Schwangerschaft erfaßt werden kann. Zusätzlich zur Wehenfrequenz und Dauer der einzelnen Wehe bilden sich die Konsisten...
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Article
The pharmacokinetics of theβ 2-adrenoceptor agonist fenoterol in healthy women
We have studied the pharmacokinetics of fenoterol in healthy women during and after a 3 h intravenous infusion of different doses within the therapeutic range for tocolysis (0.5 μg·min−1, 1.0 μg·min−1, and 2.0 μg...
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Article
Thromboxane production and platelet aggregation in type 2 diabetes mellitus without vascular complications
Diabetic individuals frequently have platelet hyperaggregability and increased thromboxane (TXB2) production. To evaluate whether improvement of metabolic control or changes in fatty acid composition of serum lip...
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Article
Steigerung der fetalen Herzfrequenz unter intravenöser und oraler Tokolyse
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Chapter and Conference Paper
Die Überwachung der Oxygenierung von Neugeborenen mit Hilfe der Pulsoximetrie
Der Übergang vom intra- zum extrauterinen Leben wird bestimmt vom Einsetzen der Lungenatmung und der Umstellung der Kreislaufverhältnisse. Beide haben Veränderungen der Blutgase und der Hämoglobinoxigenierung ...
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Chapter and Conference Paper
Steigerung der fetalen Herzfrequenz unter intravenöser und oraler Tokolyse
Betamimetika sind heute Mittel der ersten Wahl zur Behandlung von vorzeitigen Wehen in der Schwangerschaft. Die Auswirkungen auf den Feten — Herzfrequenzsteigerung, postpartale Hypoglykämie — erachtete man bis...
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Article
DECREASED INSULIN DEGRADATION AFTER GROWTH HORMONE (GH) AS ONE REGULATORY FACTOR FOR IMPROVEMENT OF INSULIN IRI IN GH DEFICIENT CHILDREN
Studies have shown the beneficial effect of normo- and hyper insulinemia on growth rate of GHD children due to craniopharyngioma (BUCHER et al.). Furthermore others showed that insulinotropic drugs improve gro...
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Article
Pharmacokinetics of ceftizoxime
The kinetics of ceftizoxime, a newly developed cephalosporin, were evaluated in 6 healthy subjects, with respect to its excretory pathways especially by the biliary route. Total, renal and biliary clearance we...
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Article
Pharmacokinetics of sulphinpyrazone and its major metabolites after a single dose and during chronic treatment
The pharmacokinetics of sulphinpyrazone and its major metabolites (sulfide, sulfone, p-hydroxysulfone and p-hydroxy-sulphinpyrazone) were investigated in 9 volunteers after a single oral dose as well as after ...
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Article
Lack of clinically important interaction between erythromycin and theophylline
In 11 healthy volunteers the kinetics of theophylline and the plasma levels and the urinary excretion of its metabolites were studied before and after treatment with erythromycin for 10 days. Theophylline was ...
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Article
Correlation between the pharmacokinetics and pharmacodynamics of dopamine in healthy subjects
The pharmacokinetics and the pharmacodynamic action of dopamine were investigated in 5 healthy subjects. Dopamine was given in different doses (200, 400 and 800 µg/min) by constant intravenous infusion over 90...
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Chapter and Conference Paper
Klinische Pharmakologie
Schwere unerwünschte Arzneimittelwirkungen (UAW) machen eine stationäre Einweisung in ein Krankenhaus erforderlich. Einen nicht unerheblichen Anteil an diesen Reaktionen bilden die Blutbildveränderungen. Im fo...
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Article
Effect of single and multiple doses of sulphinpyrazone on antipyrine metabolism and urinary excretion of 6-beta-hydroxycortisol
Sulphinpyrazone decreases the plasma clearance of tolbutamide and S-warfarin and increases the clearance of R-warfarin, theophylline and antipyrine. In order to determine whether sulphinpyrazone is an inducer ...
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Article
Lack of interaction between the tetracyclic antidepressant maprotiline and the centrally acting antihypertensive drug clonidine
The well known interaction between tricyclic antidepressants and the centrally acting antihypertensive drug clonidine, namely impairment of the antihypertensive effect of clonidine, is thought to be related to...
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Article
Intestinal absorption of levodopa in man
In four healthy subjects the intestinal absorption of levodopa (l-dopa) was investigated by measuring the plasma concentration of the amino acid following the administration of l-dopa at three different sites ...
