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Article
Aktivierung des isolierten Gefäßmuskelpräparates durch Noradrenalin, Vasopressin bzw. Depolarisation bei stufenweiser Blockade der alpha-Receptoren
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Determinations of the maximum tension development of the helical strip of rat aorta showed that the maximal r...
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Article
DIABETES MELLITUS AND VASCULAR DISEASE: POSSIBLE ROLE OF HYDROXYACIDS IN ITS GENESIS
Studies to date have not elucidated the cause(s) for diabetic neovascular proliferation. We report that a metabolite of arachidonic acid (AA), 15 hydroxyeicosatetraenoic acid (15HETE) is present in vessels, pl...
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Article
Radiation therapy and treatment results of malignant tumors of the nasal cave
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Article
14 PERSISTENT HYPERINSULINENIC HYPOGLYCEMIA OF INFANCY – LONG-TERM EXPERIENCE WITH 28 PATIENTS
We studied 28 patients with Persistent Hyperinsulinemic Hypoglycemia of Infancy (PHHI). Twenty-two developed symptomatic hypoglycemia within 2 days of life (15 of these required surgery) while 5 developed firs...
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Article
Regulation of insulin release in persistent hyperinsulinaemic hypoglycaemia of infancy studied in long-term culture of pancreatic tissue
Pancreatic tissue was obtained during therapeutic subtotal pancreatectomy from five infants with persistent hyperinsulinaemic hypoglycaemia of infancy (so-called nesidioblastosis). Collagenase digests of the s...
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Article
Effect of four multipurpose tree species on soil amelioration during tree fallow in Central Togo
The effects of Cassia siamea, Albizia lebbek, Acacia auriculiformis, and Azadirachta indica on soil fertility have been studied on five-year-old fallows on Ferric Acrisols in Central Togo. Litter quality and soil...
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Article
Familial hyperinsulinism maps to chromosome 11p14–15.1, 30 cM centromeric to the insulin gene
Familial hyperinsulinism (HI) is the most common cause of persistent neonatal hyperinsulinaemic hypoglycemia. Linkage analysis in 15 families (12 Ashkenazi Jewish, 2 consanguineous Arab, 1 non–Jewish Caucasian...
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Chapter and Conference Paper
Parallel updating algorithm for image restoration
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Article
Normal proinsulin processing despite beta-cell dysfunction in persistent hyperinsulinaemic hypoglycaemia of infancy (nesidioblastosis)
Persistent hyperinsulinaemic hypoglycaemia of infancy (PHHI) is a genetic disorder which causes severe hypoglycaemia in the neonate. The beta cells fail to respond to changes in blood glucose levels in all th...
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Article
Genes Located In and Near the Human Pseudoautosomal Region are Located in the X-Y Pairing Region in Dog and Sheep
We cloned and mapped the dog and/or sheep homologues of two human pseudoautosomal genes CSF2RA and ANT3. We also cloned and mapped dog and/or sheep homologues of STS and PRKX, which are located nearby on the diff...
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Article
Map** of the human insulin receptor substrate-2 gene, identification of a linked polymorphic marker and linkage analysis in families with Type II diabetes: no evidence for a major susceptibility role
Insulin receptor substrate 2 (IRS-2) is a substrate of the insulin receptor and mediates the action of the insulin. Disruption of the IRS-2 gene in mice results in peripheral insulin resistance and relative i...
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Article
Effects of deforestation on phosphorus pools in mountain soils of the Alay Range, Khyrgyzia
The amount, quality and turnover of soil P is heavily influenced by changes in soil management. The objective of this study was to investigate the effects of deforestation and pasture establishment on the con...
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Article
Soil organic matter quantity and quality in mountain soils of the Alay Range, Kyrgyzia, affected by land use change
Changes in soil management practices influence the amount, quality and turnover of soil organic matter (SOM). Our objective was to study the effects of deforestation followed by pasture establishment on SOM q...
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Article
Open AccessCAG and GGC repeat polymorphisms in the androgen receptor gene and breast cancer susceptibility in BRCA1/2 carriers and non-carriers
Variation in the penetrance estimates for BRCA1 and BRCA2 mutations carriers suggests that other genetic polymorphisms may modify the cancer risk in carriers. A previous study has suggested that BRCA1 carriers wi...
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Article
Isolation and characterization of the human AKT1 gene, identification of 13 single nucleotide polymorphisms (SNPs), and their lack of association with Type II diabetes
Aims/hypothesis. AKT1, a serine/threonine protein kinase, is an important downstream target of the insulin-signalling pathway, with both anti-apoptotic and peripheral metabolic effects. Because i...
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Article
Konventionelle Chromosomenanalyse an menschlichen Eizellen
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Article
Nitrogen dynamics in alpine ecosystems of the northern Caucasus
Net N mineralization, nitrification, microbial biomass N and 15N natural abundance were studied in a toposequence of representative soils and plant communities in the alpine zone of the northern Caucasus. The top...
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Article
Zusammenhang zwischen Spermiogrammparametern und chromosomalen Anomalien in Spermien
In dieser Arbeit wurde ein Zusammenhang zwischen der Aneuploidiehäufigkeit der Chromosomen 13, 16 und 21 sowie der Diploidiehäufigkeit in menschlichen Keimzellen, einer erfolglosen Fertilisation und Spermiogra...
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Article
Open AccessA single-nucleotide polymorphism in the RAD51 gene modifies breast cancer risk in BRCA2 carriers, but not in BRCA1 carriers or noncarriers
Variation in the penetrance estimates for BRCA1 and BRCA2 mutation carriers suggests that other genetic polymorphisms may modify the cancer risk in carriers. The RAD51 gene, which participates in homologous recom...
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Article
Identification of a potential Bipolar risk haplotype in the gene encoding the winged-helix transcription factor RFX4
The gene encoding the transcription factor RFX4 represents an excellent neurobiological and positional candidate gene for Bipolar disorder due to the potential involvement of RFX4 proteins in the regulation of...
